Fitzgerald/Somatostatin antibody/10-S07A/1 ml
商品编号：
10-S07A-1ml
品牌：
fitzgerald-fii
市场价：
¥12240.00
美元价：
9180.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
OVERVIEW:
| Synonyms | Monoclonal Somatostatin antibody, Anti-Somatostatin antibody, SS antibody, SST antibody, SOM antibody, Growth hormone inhibitory hormone antibody, GHIH antibody, Somatotropin release inhibiting factor antibody, SRIF antibody, Somatotropin release inhibiting hormone antibody, SRIH antibody |
|---|---|
| Cross Reactivity | Does not cross react with enkephalins, other endorphins, Substance P or CGRP. Weakly cross reacts with somatostatin fragments. |
| Applications | IHC |
| Immunogen | Somatostatin antibody was raised in rat using somatostatin conjugated to thyroglobulin as the immunogen. |
SPECIFICATIONS:
| Host | Rat |
|---|---|
| Clone | M09204 |
| Isotype | IgG2b |
| Form & Buffer | Lyophilized from 1 ml tissue culture supernatant with thimerosol. Reconsitute with 1 ml distilled water. |
STORAGE & SAFETY:
| Storage | Store at 4 deg C. Once reconstituted store in aliquots at - 20 deg C. |
|---|
Usage Assay Information:
| Usage Recommendations | IHC: 1:50-1:200 |
|---|
GENERAL INFORMATION:
| Product Use | Monoclonal Somatostatin antibody specific for Human Somatostatin for use in Immunohistochemistry. |
|---|---|
| Biological Significance | Somatostatin (somatotropin release inhibiting factor, SRIF) is an endogenous cyclic polypeptide with two biologically active forms. It is an abundant neuropeptide and has a wide range of physiological effects on neurotransmission, secretion and proliferation. The somatostatin receptor family consists of five subtypes, sst1-5, each differentially distributed throughout the central nervous system and periphery. Endogenous somatostatin receptor ligands include somatostatin-14 and somatostatin-28. Somatostatin receptors have diverse biological functions due to their varied distribution and the fact that they couple to different second messengers. They couple to adenylyl cyclase, PLC, K+ channels, Ca2+ channels and others. Somatostatin receptors in the hypothalamus are involved in the regulation of growth hormone secretion. Somatostatin regulates neuronal activity by regulating AMPA/kainate-mediated responses to glutamate. Different sst subtypes have opposing effects in this system. Somatostatin receptors also play a role in blood glucose homeostasis; sst5 receptors in the pancreatic beta-cells stimulate insulin secretion, whilst sst2 receptors are involved in glucagon secretion from alpha-cells. In addition, sst2 receptors inhibit gastric acid secretion and peristalsis in the jejunum. |
| Expression | Somatostatin receptors are expressed at many different sites in the brain. In particular, there are populations of somatostatin neurons in the arcuate nucleus, the hippocampus, and the brainstem nucleus of the solitary tract. Somatostatin is a secreted peptide hormone found in most mammalian cells and secreted heavily by the pancreas. |
| Implications in Disease | Diseases associated with SST include carcinoid syndrome, referring to the array of symptoms that occur secondary to carcinoid tumors. The syndrome includes flushing and diarrhea, and, less frequently, heart failure and bronchoconstriction. It is caused by endogenous secretion of mainly serotonin and kallikrein, and somatostatinoma, a malignant tumor of the delta cells of the endocrine pancreas that produces somatostatin. |
| Sequence Information | SST belongs to the peptide hormone family and is composed of 116 amino acids with a molecular weight of 12736 Da. There is a signal peptide at positions 1-24. |
| Post-Translational Modifications | Glycosylation occurs at Asn61. |
| Database Links | Entrez Gene: 6750, Ensembl: ENSG00000157005, euGenes: HUgn6750 |
品牌介绍
美国Fitzgerald 公司是一家国际性知名抗体研发生产企业。Fitzgerald公司为全球试剂诊断公司与研究机构提供专业的抗体、纯化抗原以及工业诊断用大包装免疫原料。公司产品多达5000种，能够满足您对于最前沿科学研究的需求。产品涉及：单克隆抗体／抗原生育类、传染病类、TORCH系列、肿瘤标记物、心脏标记物、神经科学类、病毒类等等。
品牌分类
重组蛋白
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