Fitzgerald/CD71 antibody/10R-CD71aHU/100 ug
商品编号：
10R-CD71aHU-100ug
品牌：
fitzgerald-fii
市场价：
¥8240.00
美元价：
6180.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
OVERVIEW:
| Synonyms | MonoclonalCD71antibody,Anti-CD71antibody,CD-71,CD71,CD71antibody,CD-71antibody,CD71 |
|---|---|
| Specificity | Human |
| CrossReactivity | Tobedeterminedbyend-user |
| Applications | FC |
| Immunogen | CD71antibodywasraisedinmouseusinghumanCD71astheimmunogen. |
SPECIFICATIONS:
| Host | Mouse |
|---|---|
| Clone | RVS-10 |
| Isotype | IgG1 |
| Form&Buffer | Suppliedasaliquidin100mMBBS,pH8.2. |
| Concentration | 0.1mg/ml |
STORAGE&SAFETY:
| Storage | Storeat4degC. |
|---|
UsageAssayInformation:
| UsageRecommendations | Optimalconditionstobedeterminedbyenduser |
|---|
GENERALINFORMATION:
| ProductUse | MonoclonalCD71antibodyspecificforHumanCD71foruseinFlowCytometry. |
|---|---|
| BIOLOGicalSignificance | CD71isthetransferrinreceptor.CD71regulatesthecellularuptakeofironoccursviareceptor-mediatedendocytosisofligand-occupiedreceptorsintospecializedendosomes.Endosomalacidificationleadstoironrelease.Theapotransferrin-receptorcomplexisthenrecycledtothecellsurfacewithareturntoneutralpHandtheconcomitantlossofaffinityofapotransferrinforitsreceptor.Transferrinreceptorisnecessaryfordevelopmentoferythrocytesandthenervoussystem. |
| Expression | CD71isexpressedinawiderangeofcelltypesandtissues.Expressionlevelishighestinlymphocytes,placentaandneoplasticcells.CD71isasingle-passtypeIImembraneproteinlocalizedtothecellmembrane. |
| ImplicationsinDisease | OverexpressionofCD71inmalignantcellsmediateshigherironuptakerequiredforcelldivision.Expressionisactivatedbyc-Myc.NomutationorvariationinCD71causescancerandCD71isnotinvolvedincancer-associatedtranslocations.CD71variantS142GmodifiestheassociationsofHFEC282Ymutationincancersusceptibilityforhepatocellularcarcinoma,breastcancer,leukemia,colorectalcancerandmultiplemyeloma.Biologicalplausibilityoftheseassociationshasbeensupportedbythesuccessfuluseofmonoclonalantibodiesagainsttransferrinreceptorincancertreatmentinvitroandinvivo.Therearenodisease-causingmutationsintheCD71gene.However,therearemissensecodingregionvariantsthatmayhavefunctionaleffects.Theonlyonewithappreciablefrequency(rs3817672)isinexon4andencodesS142Gaminoacidsubstitution.Thispolymorphismdoesnothaveahomogeneousglobaldistribution.ItsminoralleleinCaucasiansisthemajoralleleinAsiansandAfricans. |
| SequenceInformation | CD71iscomposedof760aminoacidswithamolecularweightof84871Da. |
| Post-TranslationalModifications | D71isN-andO-glycosylated,phosphorylatedandpalmitoylated.TheserumformisonlyglycosylatedCD71isproteolyticallycleavedonArg-100toproducethesolubleserumform(sTfR)andispalmitoylatedonbothCys-62andCys-67.Cys-62seemstobethemajorsiteofpalmitoylation.ThereisalsoubiquitinationatLys39,Lys224,Lys344,Lys358,Lys720andglycosylationatThr104,Asn251,Asn317,Asn727. |
| DatabaseLinks | EntrezGene:7037Human,Omim:190010Human,SwissProt:P02786Human,Unigene:529618Human |
品牌介绍
美国Fitzgerald 公司是一家国际性知名抗体研发生产企业。Fitzgerald公司为全球试剂诊断公司与研究机构提供专业的抗体、纯化抗原以及工业诊断用大包装免疫原料。公司产品多达5000种，能够满足您对于最前沿科学研究的需求。产品涉及：单克隆抗体／抗原生育类、传染病类、TORCH系列、肿瘤标记物、心脏标记物、神经科学类、病毒类等等。
品牌分类
重组蛋白
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