Fitzgerald/Neu antibody/10R-N105d/100 ug
商品编号：
10R-N105d-100ug
品牌：
fitzgerald-fii
市场价：
¥12500.00
美元价：
9375.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
OVERVIEW:
| Synonyms | Monoclonal Neu antibody, Anti-Neu antibody |
|---|---|
| Cross Reactivity | Human, mouse, rat |
| Applications | IF, IHC, WB |
| Immunogen | Neu antibody was raised in mouse using tyrosine-phosphorylated synthetic peptide corresponding to amino acids 1242-1255 from the C-terminus of human c-erbB-2 protein. as the immunogen. |
SPECIFICATIONS:
| Host | Mouse |
|---|---|
| Clone | PN2A |
| Isotype | IgG1 |
| Method of Purification | Neu antibody was purified by Protein A chromatography. |
| Molecular Weight | 185 kDa (predicted detection band MW) |
| Form & Buffer | Antibody purified from Ascites fluid by Protein G Chromotography and supplied in 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% NaN3. |
| Concentration | Batch dependent - please inquire should you have specific requirements |
STORAGE & SAFETY:
| Storage | Store at 4 deg C. |
|---|---|
| Biohazard Information | This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling. |
Usage Assay Information:
| Usage Recommendations | Optimal conditions to be determined by end user |
|---|
GENERAL INFORMATION:
| Biological Significance | c-erbB-2 (HER-2/neu) is a 185 kDa receptor tyrosine kinase belonging to the epidermal growth factor receptor family, which also includes EGFR (HER-1), c-erbB-3 (HER-3), and c-erbB-4 (HER-4). Amplification of the HER-2 gene with overexpression of the protein occurs in 20-30% of breast cancers and tumor progression in mammary cancer is associated with elevated levels of tyrosine-phosphorylated neu and erbB-3. Tyr1248 is the phosphorylation site that is most tightly linked to oncogenic transformation and coupling to the ras/MAP kinase signaling pathway. Cases of invasive breast carcinoma with the phosphorylated receptor have displayed aggressive clinicopathological features and adverse prognoses. Activation of HER-2 is frequent in ductal carcinoma in situ suggesting that HER-2 signaling plays a critical role in the early stages of breast tumorigenesis. |
|---|
品牌介绍
美国Fitzgerald 公司是一家国际性知名抗体研发生产企业。Fitzgerald公司为全球试剂诊断公司与研究机构提供专业的抗体、纯化抗原以及工业诊断用大包装免疫原料。公司产品多达5000种，能够满足您对于最前沿科学研究的需求。产品涉及：单克隆抗体／抗原生育类、传染病类、TORCH系列、肿瘤标记物、心脏标记物、神经科学类、病毒类等等。
品牌分类
重组蛋白
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