菲茨杰拉德/纤维连接蛋白抗体/10R-F110b/100微克
商品编号：
10R-F110b-100ug
品牌：
fitzgerald-fii
市场价：
¥9680.00
美元价：
7260.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
OVERVIEW:
| Synonyms | Monoclonal Fibronectin antibody, Anti-Fibronectin antibody, CIG antibody, LETS antibody, Migration stimulating factor antibody, Cold insoluble globulin antibody, MSF antibody, Transformation sensitive protein antibody |
|---|---|
| Cross Reactivity | Human, mouse, rat |
| Applications | IF |
| Immunogen | Fibronectin antibody was raised in mouse using recombinant fibronectin protein as the immunogen. |
SPECIFICATIONS:
| Host | Mouse |
|---|---|
| Clone | FBN11 |
| Isotype | IgG1 |
| Method of Purification | Fibronectin antibody was purified by Protein G chromatography. |
| Molecular Weight | 440 kDa (non-reduced), 220kDa (reduced) |
| Form & Buffer | Antibody purified from Ascites fluid by Protein G Chromotography and supplied in 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% NaN3. |
| Concentration | 0.2 mg/ml |
STORAGE & SAFETY:
| Storage | Store at 4 deg C. |
|---|---|
| Biohazard Information | This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling. |
Usage Assay Information:
| Usage Recommendations | Optimal conditions to be determined by end user |
|---|
GENERAL INFORMATION:
| Product Use | Monoclonal FN1 antibody specific for Human Fibronectin 1 for use in Immunofluorescence. |
|---|---|
| Biological Significance | Fibronectin is a high-molecular weight glycoprotein of the extracellular matrix that binds to membrane-spanning receptor proteins called integrins. Similar to integrins, fibronectin binds extracellular matrix components such as collagen, fibrin, and heparan sulfate proteoglycans. Fibronectin has numerous functions that ensure the normal functioning of vertebrate organisms. It is involved in cell adhesion, growth, migration, and differentiation. Cellular fibronectin is assembled into the extracellular matrix, an insoluble network that separates and supports the organs and tissues of an organism. |
| Expression | Altered fibronectin expression, degradation, and organization has been associated with a number of pathologies, including cancer and fibrosis. |
| Implications in Disease | Defects in FN1 are the cause of glomerulopathy with fibronectin deposits type 2 (GFND2); also known as familial glomerular nephritis with fibronectin deposits or fibronectin glomerulopathy. GFND is a genetically heterogeneous autosomal dominant disorder characterized clinically by proteinuria, microscopic hematuria, and hypertension that leads to end-stage renal failure in the second to fifth decade of life. Mutations in fibronectin expression, degradation, and organization have been associated with a number of pathologies, including cancer and fibrosis. Fibronectin has been implicated in carcinoma development. In lung carcinoma, fibronectin expression is increased, especially in non-small cell lung carcinoma. The adhesion of lung carcinoma cells to fibronectin enhances tumorigenicity and confers resistance to apoptosis-inducing chemotherapeutic agents. |
| Sequence Information | FN1 is composed of 2386 amino acids with a molecular weight of 262625 Da. There is a DNA binding region at 907 – 1172, 2 fibronectin type-I domains, 2 fibronectin type-II domains and 16 fibronectin type-III domains. |
| Post-Translational Modifications | FN1 forms covalent cross-links mediated by a transglutaminase, such as F13A or TGM2, between a glutamine and the epsilon-amino group of a lysine residue, forming homopolymers and heteropolymers (e.g. fibrinogen-fibronectin, collagen-fibronectin heteropolymers). Phosphorylation sites are present in the extracellular medium. Proteolytic processing produces the C-terminal NC1 peptide, anastellin. FN1 undergoes ubiquitination at Lys1050 and glycosylation at Thr278, Thr279, Ser280, Ser281, Ser283, Thr287, Asn430, Asn528, Asn542, Asn877, Asn1007, Asn1244, Thr1276, Ser1565, Ser1566, Ser1567, Thr1570, Thr1641, Thr1999, Thr2060. |
| Database Links | Entrez Gene: 2335 Human, Omim: 135600 Human, SwissProt: P02751 Human, Unigene: 203717 Human. |
品牌介绍
美国Fitzgerald 公司是一家国际性知名抗体研发生产企业。Fitzgerald公司为全球试剂诊断公司与研究机构提供专业的抗体、纯化抗原以及工业诊断用大包装免疫原料。公司产品多达5000种，能够满足您对于最前沿科学研究的需求。产品涉及：单克隆抗体／抗原生育类、传染病类、TORCH系列、肿瘤标记物、心脏标记物、神经科学类、病毒类等等。
品牌分类
重组蛋白
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