Fitzgerald/Pin1 antibody/10R-1035/100 ul
商品编号：
10R-1035-100ul
品牌：
fitzgerald-fii
市场价：
¥5300.00
美元价：
3975.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
OVERVIEW:
| Synonyms | Monoclonal Pin1 antibody, Anti-Pin1 antibody, PPIase antibody, Pin1, Rotamase Pin1 antibody, Pin 1, Pin 1 antibody, PIN1 antibody, PPIase Pin1 antibody, EC 5.2.1.8 antibody, PIN1 antibody, Pin-1 antibody, PPIase Pin1 antibody, EC 5.2.1.8 antibody, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 antibody, Pin-1, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 antibody, Rotamase Pin1 antibody, UBL5 antibody, DOD antibody |
|---|---|
| Specificity | Human |
| Cross Reactivity | To be determined by end-user. |
| Applications | ELISA, WB |
| Immunogen | Pin1 antibody was raised in mouse using recombinant human Pin1 (1-163aa) purified from E. coli as the immunogen. |
SPECIFICATIONS:
| Host | Mouse |
|---|---|
| Clone | 3G8 |
| Isotype | IgG1 kappa |
| Source | Anti-human Pin1 antibody, clone 3G8, is derived from hybridization of mouse SP2/O myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human Pin1 protein. |
| Method of Purification | Pin1 antibody was purified by protein-G affinity chromatography |
| Form & Buffer | Supplied as a liquid in PBS, pH 7.4, with 0.1% NaN3. |
| Concentration | 1 mg/ml |
STORAGE & SAFETY:
| Storage | Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles. |
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Usage Assay Information:
| Usage Recommendations | WB: 1:500-1:1,000 |
|---|
GENERAL INFORMATION:
| Biological Significance | Human Pin 1 is a peptidyl-prolyl cis/trans isomerase (PPIase) that interacts with NIMA and essential for cell cycle regulation. Pin1 is nuclear PPIase containing a WW protein interaction domain, and is structurally and functionally related to Ess1/Ptf1, an essential protein in budding yeast. PPIase activity is necessary for Ess1/Pin1 function in yeast. Pin1 is thus an essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Substrates of Pin1 include the mitotic regulators (Cdc25 phosphatase and NIMA ,PLk I, Wee, and Myt1 kinases), several transcription factors likebeta-Catenin, c-Jun, and the tumor suppressor protein p53 , and some specific proteins like the RNA Pol II, the cytoskeleton protein tau, and the G1/S protein Cyclin D1. |
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品牌介绍
美国Fitzgerald 公司是一家国际性知名抗体研发生产企业。Fitzgerald公司为全球试剂诊断公司与研究机构提供专业的抗体、纯化抗原以及工业诊断用大包装免疫原料。公司产品多达5000种，能够满足您对于最前沿科学研究的需求。产品涉及：单克隆抗体／抗原生育类、传染病类、TORCH系列、肿瘤标记物、心脏标记物、神经科学类、病毒类等等。
品牌分类
重组蛋白
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