Fitzgerald/APP antibody/10R-1097/100 ul
商品编号：
10R-1097-100ul
品牌：
fitzgerald-fii
市场价：
¥5300.00
美元价：
3975.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
OVERVIEW:
| Synonyms | Monoclonal APP antibody, Anti-APP antibody, isoform antibody, peptidase nexin-II antibody, amyloid beta (A4) precursor protein antibody, amyloid beta A4 protein precursor antibody, Alzheimer disease antibody |
|---|---|
| Specificity | Human |
| Cross Reactivity | Human, Mouse |
| Applications | ELISA, WB |
| Immunogen | APP antibody was raised in mouse using recombinant human APP (18-289aa) purified from E. coli as the immunogen. |
SPECIFICATIONS:
| Host | Mouse |
|---|---|
| Clone | J4H9 |
| Isotype | IgG2b kappa |
| Source | Anti-human APP antibody, clone J4H9, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human APP protein. |
| Method of Purification | APP antibody was purified by protein-G affinity chromatography |
| Form & Buffer | Supplied as a liquid in PBS, pH 7.4, with 0.1% NaN3. |
| Concentration | 1 mg/ml |
STORAGE & SAFETY:
| Storage | Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles. |
|---|
Usage Assay Information:
| Usage Recommendations | WB: 1:1000-1:2,000 |
|---|
GENERAL INFORMATION:
| Biological Significance | Amyloid precursor protein (APP) is the precursor molecule whose proteolysis generates amyloid beta, a 39- to 42- amino acid peptide and this amyloid fibrillar form is the primary component of amyloid plaques found in the brains of Alzheimer?s disease patients. APP is an integral membrane protein that is phosphorylated in the cytoplasmic and extracellular domains. It has been reported that cell-surface APP plays a role in neurite extension of primary cultured hippocampal neurons. The large extracellular domain of APP is also reported to bind extracellular matrix molecules such as heparin, laminin, and collagen, which can mediate cell adhesion and neurite outgrowth. Abnormal regulation of the metabolism of APP may contribute to the deposition of plaques. |
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品牌介绍
美国Fitzgerald 公司是一家国际性知名抗体研发生产企业。Fitzgerald公司为全球试剂诊断公司与研究机构提供专业的抗体、纯化抗原以及工业诊断用大包装免疫原料。公司产品多达5000种，能够满足您对于最前沿科学研究的需求。产品涉及：单克隆抗体／抗原生育类、传染病类、TORCH系列、肿瘤标记物、心脏标记物、神经科学类、病毒类等等。
品牌分类
重组蛋白
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