Fitzgerald/BARD1 antibody/10R-1310/50 ug
商品编号：
10R-1310-50ug
品牌：
fitzgerald-fii
市场价：
¥8920.00
美元价：
6690.00
产品分类：
单克隆抗体
公司分类：
monoclonal_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
OVERVIEW:
| Synonyms | Monoclonal BARD1 antibody, Anti-BARD1 antibody, BRCA1 associated RING domain gene 1 antibody, BARD-1 antibody, BARD 1, BARD1, BARD-1, BARD 1 antibody |
|---|---|
| Specificity | Human BARD1 |
| Cross Reactivity | Human. Other species not studied |
| Applications | Dot Blot, IP, WB |
| Immunogen | BARD1 antibody was raised in mouse using recombinant Human Brca1 Associated Ring Domain 1 (Bard1) |
SPECIFICATIONS:
| Host | Mouse |
|---|---|
| Clone | 2059C4a |
| Isotype | IgG1 |
| Method of Purification | BARD1 antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum. |
| Form & Buffer | BARD1 antibody in PBS (3.0 mM KCl, 1.5 mM KH2 PO4 , 140 mM NaCl, 8.0 mM Na2 HPO4 (pH 7.4)) containing 1% bovine serum albumin (BSA) and 0.05% sodium azide (NaN3 ). |
| Concentration | 100 ug/ml |
STORAGE & SAFETY:
| Storage | Store at 2-8 deg C for up to one year. We recommend long term storage at -20 deg C. Avoid repeated freezing and thawing. |
|---|---|
| Biohazard Information | This antibody solution contains sodium azide (NaN ) as a preservative. There is a potential hazard that NaN reacts with copper or lead to produce an explosive compound. For safe disposal, the vial has to be washed thoroughly with water. It is strongly adv |
Usage Assay Information:
| Usage Recommendations | WB: 0.2-2 ug/ml, IP: 100-500 ug/sample |
|---|
GENERAL INFORMATION:
| Biological Significance | BARD1 interacts with the N-terminal region of BRCA1. In addition to its ability to bind BRCA1 in vivo and in vitro, BARD1 shares homology with the 2 most conserved regions of BRCA1: the N-terminal RING motif and the C-terminal BRCT domain. The RING motif is a cysteine-rich sequence found in a variety of proteins that regulate cell growth, including the products of tumor suppressor genes and dominant protooncogenes. The BARD1 protein also contains 3 tandem ankyrin repeats. The BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid substitutions in BRCA1, implying that the formation of a stable complex between these proteins may be an essential aspect of BRCA1 tumor suppression. BARD1 may be the target of oncogenic mutations in breast or ovarian cancer. |
|---|
品牌介绍
美国Fitzgerald 公司是一家国际性知名抗体研发生产企业。Fitzgerald公司为全球试剂诊断公司与研究机构提供专业的抗体、纯化抗原以及工业诊断用大包装免疫原料。公司产品多达5000种，能够满足您对于最前沿科学研究的需求。产品涉及：单克隆抗体／抗原生育类、传染病类、TORCH系列、肿瘤标记物、心脏标记物、神经科学类、病毒类等等。
品牌分类
重组蛋白
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