Fitzgerald/CBLB antibody/10R-1493/50 ug
商品编号：
10R-1493-50ug
品牌：
fitzgerald-fii
市场价：
¥8920.00
美元价：
6690.00
产品分类：
单克隆抗体
公司分类：
monoclonal_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
OVERVIEW:
| Synonyms | MonoclonalCBLBantibody,Anti-CBLBantibody,Nbla00127antibody,RNF56antibody,Cas-Br-M(murine)ecotropicretroviraltransformingsequencebantibody |
|---|---|
| Specificity | HumanCBLB |
| CrossReactivity | Human,Mouse.Otherspeciesnotstudied |
| Applications | DotBlot,WB |
| Immunogen | CBLBantibodywasraisedinmouseusingrecombinantHumanCas-Br-M(Murine)EcotropicRetroviralTransformingSequenceB |
SPECIFICATIONS:
| Host | Mouse |
|---|---|
| Clone | 246C5a |
| Isotype | IgG2a |
| MethodofPurification | CBLBantibodywaspurifiedusingproteinGcolumnchromatographyfromculturesupernatantofhybridomaculturedinamediumcontainingbovineIgG-depleted(approximately95%)fetalbovineserum. |
| Form&Buffer | CBLBantibodyinPBS(3.0mMKCl,1.5mMKH2PO4,140mMNaCl,8.0mMNa2HPO4(pH7.4))containing1%bovineserumalbumin(BSA)and0.05%sodiumazide(NaN3). |
| Concentration | 100ug/ml |
STORAGE&SAFETY:
| Storage | Storeat2-8degCforuptooneyear.Werecommendlongtermstorageat-20degC.Avoidrepeatedfreezingandthawing. |
|---|---|
| BiohazardInformation | Thisantibodysolutioncontainssodiumazide(NaN)asapreservative.ThereisapotentialhazardthatNaNreactswithcopperorleadtoproduceanexplosivecompound.Forsafedisposal,thevialhastobewashedthoroughlywithwater.Itisstronglyadv |
UsageAssayInformation:
| UsageRecommendations | WB:0.2-2ug/ml |
|---|
GENERALINFORMATION:
| BIOLOGicalSignificance | E3ubiquitin-proteinligasewhichacceptsubiquitinfromspecificE2ubiquitin-conjugatingenzymes,andtransfersittosubstrates,generallypromotingtheirdegradationbytheproteasome.NegativelyregulatesTCR(T-cellreceptor),BCR(B-cellreceptor)andFCER1(highaffinityimmunoglobulinepsilonreceptor)signaltransductionpathways.InnaiveT-cells,inhibitsVAV1activationuponTCRengagementandimposesarequirementforCD28costimulationforproliferationandIL-2production.AlsoactsbypromotingPIK3R1/p85ubiquitination,whichimpairsitsrecruitmenttotheTCRandsubsequentactivation.InactivatedT-cells,inhibitsPLCG1activationandcalciummobilizationuponrestimulationandpromotesanergy. |
|---|
品牌介绍
美国Fitzgerald 公司是一家国际性知名抗体研发生产企业。Fitzgerald公司为全球试剂诊断公司与研究机构提供专业的抗体、纯化抗原以及工业诊断用大包装免疫原料。公司产品多达5000种，能够满足您对于最前沿科学研究的需求。产品涉及：单克隆抗体／抗原生育类、传染病类、TORCH系列、肿瘤标记物、心脏标记物、神经科学类、病毒类等等。
品牌分类
重组蛋白
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