菲茨杰拉德/FGFR1抗体/10R-1810/100微升
商品编号：
10R-1810-100ul
品牌：
fitzgerald-fii
市场价：
¥6900.00
美元价：
5175.00
产品分类：
单克隆抗体
公司分类：
monoclonal_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
OVERVIEW:
| Synonyms | MonoclonalFGFR1antibody,Anti-FGFR1antibody,FGFR-1,fms-relatedtyrosinekinase-2antibody,Pfeiffersyndromeantibody,FGFR1,FGFR1antibody,FGFR-1antibody,basicfibroblastgrowthfactorreceptor1antibody,Fibroblastgrowthfactorreceptor1antibody,CD331antibody,FGFR1 |
|---|---|
| CrossReactivity | Human |
| Applications | ELISA,WB |
| Immunogen | FGFR1antibodywasraisedinMouseusingpurifiedrecombinantextracellularfragmentofhumanFGFR1(aa33-423)fusedwithhIgGFctagexpressedinHEK293cellsastheimmunogen. |
SPECIFICATIONS:
| Host | Mouse |
|---|---|
| Clone | 3D4F7 |
| Isotype | IgG2b |
| Form&Buffer | Suppliedasaliquidinasciticfluidcontaining0.03%sodiumazide. |
| Concentration | 1.0mg/ml |
STORAGE&SAFETY:
| Storage | Storeat4degCforshorttermstorage.Storeat-20degCforlongtermstorage.Avoidrepeatedfreeze/thawcycles. |
|---|
UsageAssayInformation:
| UsageRecommendations | ELISA:1:10,000,WB:1:500-1:2000 |
|---|
GENERALINFORMATION:
| BIOLOGicalSignificance | ProductUses:MonoclonalFGFR1antibodyspecificforHumanFGFR1foruseinELISAandWesternBlot.BiologicalSignificance:FGFR1areceptortyrosinekinaseofthehighly-conservedfibroblastgrowthfactorreceptor(FGFR).FGFR1bindsbothacidicandbasicfibroblastgrowthfactorsandisinvolvedinlimbinduction.PointmutationscausePfeffersyndrome(fingerandtoemalformationsandotherskeletalerrors)anddominantKallmannsyndrome2.Stemcellleukemialymphomasyndrome(SCLL)maybecausedbyat(8;13)(p12;q12)translocationthatfusesazincfingergene,ZNF198,toFGFR1.VariousmyeloproliferativedisordershavebeenlinkedtotranslocationsthatfuseFGFR1toFOP,FIM,CEP1ortheatypicalkinase,Bcr.Inhibitor:SU5402.TissueandCellLocalization:FGFR1isintegraltotheplasmamembrane,cytoplasmicmembrane-boundvesicles,thecytosolandthenucleus.CytogeneticLocation:8p11.23-p11.22.MolecularLocationonchromosome8:basepairs38,411,137to38,468,833ImplicationsinDisease:DefectsintheFGFR1genehavebeenwidelyreportedinanumberofdiseaseconditionsincludingseveralmelonomas:Kallmannsyndrome;rhaveidentifiedmorethan40FGFR1genemutationsthatcauseKallmannsyndrometype2,whichisaconditioncharacterizedbydelayedorabsentpubertyandanimpairedsenseofsmell.8p11myeloproliferative;TheFGFR1geneisinvolvedinatypeofbloodcancercalled8p11myeloproliferativesyndrome.Thisconditionischaracterizedbyanincreasednumberofwhitebloodcells(myeloproliferativedisorder)andthedevelopmentoflymphoma,ablood-relatedcancerthatcausestumorformationinthelymphnodes.Osteoglophonicdysplasia;SeveralmutationsintheFGFR1genecancausearareconditioncalledosteoglophonicdysplasia.Thisconditionischaracterizedbyabnormalbonegrowththatleadstoheadandface(craniofacial)abnormalitiesanddwarfism.FGFR1genemutationsthatcauseosteoglophonicdysplasiachangesingleaminoacidsintheFGFR1protein.ThealteredFGFR1proteinappearstocauseprolongedsignaling,whichpromotesprematurefusionofbonesintheskullanddisruptstheregulationofbonegrowthinthearmsandlegs,leADIngtocraniofacialabnormalitiesandshortenedlimbs.Pfeiffersyndrome:SimilartoOsteoglophonicdysplasia.Cancers:Alterationsintheactivity(expression)oftheFGFR1geneareassociatedwithcertaincancers.Thealteredgeneexpressionmayenhanceseveralcancer-relatedeventssuchascelldivision,cellmovement,andthedevelopmentofnewbloodvesselsthatnourishagrowingtumor.TheFGFR1geneisabnormallyactive(overexpressed)incertaintypesofstomachandprostatecancers.SequenceInformation:FGFR1belongstothefibroblastgrowthfactorreceptorsubfamilywhereaminoacidsequenceishighlyconservedbetweenmembersandthroughoutevolution.FGFR1consistsofanextracellularregion,composedofthreeimmunoglobulin-likedomains,asinglehydrophobicmembrane-spanningsegmentandacytoplasmictyrosinekinasedomain.Post-TranslationalModifications:Autophosphorylated:BindingofFGFfamilymemberstogetherwithheparansulfateproteoglycanorheparinpromotesreceptordimerizationandautophosphorylationontyrosineresidues.Ubiquitinated:FGFR1israpidlyubiquitinatedbyNEDD4afterautophosphorylation,leadingtointernalizationandlysosomaldegradation.N-glycosylatedintheendoplasmicreticulum:TheN-glycanchainsundergofurthermaturationtoanEndoH-resistantformintheGolgiapparatusDatabaseReferences:EntrezGene:2260Human,Omim:136350Human,SwissProt:P11362Human,Unigene:264887Human |
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品牌介绍
美国Fitzgerald 公司是一家国际性知名抗体研发生产企业。Fitzgerald公司为全球试剂诊断公司与研究机构提供专业的抗体、纯化抗原以及工业诊断用大包装免疫原料。公司产品多达5000种，能够满足您对于最前沿科学研究的需求。产品涉及：单克隆抗体／抗原生育类、传染病类、TORCH系列、肿瘤标记物、心脏标记物、神经科学类、病毒类等等。
品牌分类
重组蛋白
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