Fitzgerald/KDR antibody/10R-1869/100 ul
商品编号：
10R-1869-100ul
品牌：
fitzgerald-fii
市场价：
¥6900.00
美元价：
5175.00
产品分类：
单克隆抗体
公司分类：
monoclonal_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
OVERVIEW:
| Synonyms | MonoclonalKDRantibody,Anti-KDRantibody,VEFR2antibody,Vascularendothelialgrowthfactorreceptor2antibody,CD309antibody,Clusterofdifferentiation309antibody,Flk1antibody,Fetalliverkinase1antibody,MonoclonalKDRantibody,Anti-KDRantibody,VEFR2antibody,Vascularendothelialgrowthfactorreceptor2antibody,CD309antibody,Clusterofdifferentiation309antibody,Flk1antibody,Fetalliverkinase1antibody |
|---|---|
| CrossReactivity | Human |
| Applications | ELISA,FC,IF,WB |
| Immunogen | KDRantibodywasraisedinMouseusingpurifiedrecombinantextracellularfragmentofhumanKDR(aa20-764)fusedwithhIgGFctagexpressedinHEK293cellsastheimmunogen. |
SPECIFICATIONS:
| Host | Mouse |
|---|---|
| Clone | 4B4 |
| Isotype | IgG1 |
| Form&Buffer | Suppliedasaliquidinasciticfluidcontaining0.03%sodiumazide. |
| Concentration | 1.0mg/ml |
STORAGE&SAFETY:
| Storage | Storeat4degCforshorttermstorage.Storeat-20degCforlongtermstorage.Avoidrepeatedfreeze/thawcycles. |
|---|
UsageAssayInformation:
| UsageRecommendations | ELISA:1:10,000,FC:1:200-1:400,IF:1:200-1:1000,WB:1:500-1:2000 |
|---|
GENERALINFORMATION:
| ProductUse | MonoclonalKDRantibodyspecificforHumanKDRforuseinELISA,FlowCytometryandWesternBlot. |
|---|---|
| BIOLOGicalSignificance | KDRisatyrosine-proteinkinasethatactsasacell-surfacereceptorforVEGFA,VEGFCandVEGFD.Itplaysanessentialroleintheregulationofangiogenesis,vasculardevelopment,vascularpermeABIlity,andembryonichematopoiesis.KDRpromotesproliferation,survival,migrationdifferentiationofendothelialcellsandpromotesreorganizationoftheactinCytoskeleton.Isoformslackingatransmembranedomain,suchasisoform2andisoform3,mayfunctionasdecoyreceptorsforVEGFA,VEGFCand/orVEGFD.Isoform2playsanimportantroleasnegativeregulatorofVEGFA-andVEGFC-mediatedlymphangiogenesisbylimitingtheamountoffreeVEGFAand/orVEGFCandpreventingtheirbindingtoFLT4.ModulatesFLT1andFLT4signalingbyformingheterodimers.Bindingofvasculargrowthfactorstoisoform1leadstotheactivationofseveralsignalingcascades.ActivationofPLCG1leadstotheproductionofthecellularsignalingmoleculesdiacylglycerolandinositol1,4,5-trisphosphateandtheactivationofproteinkinaseC.KDRalsomediatesactivationofMAPK1/ERK2,MAPK3/ERK1andtheMAPkinasesignalingpathway,aswellasoftheAKT1signalingpathway.MediatesphosphorylationofPIK3R1,theregulatorysubunitofphosphatidylinositol3-kinase,reorganizationoftheactincytoskeletonandactivationofPTK2/FAK1. |
| Expression | KDRbelongstotheTyrproteinkinasefamilyandiswidelyexpressedthroughoutmammaliancells.KDRisfoundinthecellmembraneandishighlyexpressedinthecornea. |
| ImplicationsinDisease | DefectsinKDRareassociatedwithsusceptibilitytohemangiomacapillaryinfantile(HCI).HCIarebenign,highlyproliferativelesionsinvolvingaberrantlocalizedgrowthofcapillaryendothelium.Theyarethemostcommontumorofinfancy,occurringinupto10%ofallbirths.Hemangiomastendtoappearshortlyafterbirthandshowrapidneonatalgrowthforupto12monthscharacterizedbyendothelialhypercellularityandincreasednumbersofmastcells.Thisphaseisfollowedbyslowinvolutionatarateofabout10%peryearandreplacementbyfibrofattystroma. |
| SequenceInformation | KDRcontains1356aminoacidsandhasamolecularweightof151527Da |
| Post-TranslationalModifications | Autophosphorylatedontyrosineresiduesuponligandbinding.Autophosphorylationoccursintrans,i.e.onesubunitofthedimericreceptorphosphorylatestyrosineresiduesontheothersubunit.PhosphorylationatTyr-951isimportantforinteractionwithSH2D2A/TSADandVEGFA-mediatedreorganizationoftheactincytoskeleton.PhosphorylationatTyr-1175isimportantforinteractionwithPLCG1andSHB.PhosphorylationatTyr-1214isimportantforinteractionwithNCK1andFYN.DephosphorylatedbyPTPRB.DephosphorylatedbyPTPRJatTyr-951,Tyr-996,Tyr-1054,Tyr-1059,Tyr-1175andTyr-1214. |
| DatabaseLinks | EntrezGene:3791Human,Omim:191306Human,SwissProt:P35968Human,Unigene:479756Human |
品牌介绍
美国Fitzgerald 公司是一家国际性知名抗体研发生产企业。Fitzgerald公司为全球试剂诊断公司与研究机构提供专业的抗体、纯化抗原以及工业诊断用大包装免疫原料。公司产品多达5000种，能够满足您对于最前沿科学研究的需求。产品涉及：单克隆抗体／抗原生育类、传染病类、TORCH系列、肿瘤标记物、心脏标记物、神经科学类、病毒类等等。
品牌分类
重组蛋白
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