Fitzgerald/ICAM1 antibody/10R-1892/100 ul
商品编号：
10R-1892-100ul
品牌：
fitzgerald-fii
市场价：
¥6500.00
美元价：
4875.00
产品分类：
单克隆抗体
公司分类：
monoclonal_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
OVERVIEW:
| Synonyms | Monoclonal ICAM1 antibody, Anti-ICAM1 antibody, Intercellular adhesion molecule 1 antibody, ICAM 1, ICAM1, CD54 antigen antibody, ICAM-1 antibody, ICAM-1 antibody, major group rhinovirus receptor antibody, ICAM 1 antibody, ICAM-1 |
|---|---|
| Cross Reactivity | Human |
| Applications | ELISA, WB |
| Immunogen | ICAM1 antibody was raised in Mouse using a purified recombinant fragment of human ICAM1(28-480aa) expressed in E. coli as the immunogen. |
SPECIFICATIONS:
| Host | Mouse |
|---|---|
| Clone | 6G12 |
| Isotype | IgG1 |
| Form & Buffer | Supplied as a liquid in ascitic fluid containing 0.03% sodium azide. |
| Concentration | 1.0 mg/ml |
STORAGE & SAFETY:
| Storage | Store at 4 deg C for short term storage. Store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles. |
|---|
Usage Assay Information:
| Usage Recommendations | ELISA: 1:10,000, WB: 1:500-1:2000 |
|---|
GENERAL INFORMATION:
| Product Use | Monoclonal ICAM1 antibody specific for Human ICAM1 for use in ELISA and Western Blot. |
|---|---|
| Biological Significance | ICAM1 is a member of the immunoglobulin superfamily, the superfamily of proteins including antibodies and T-cell receptors. ICAM1 is a transmembrane protein possessing an amino-terminus extracellular domain, a single transmembrane domain, and a carboxy-terminus cytoplasmic domain. ICAM1 is known for its importance in stabilizing cell-cell interactions and facilitating leukocyte endothelial transmigration. More recently, ICAM1 has been characterized as a site for the cellular entry of human rhinovirus. Because of these associations with immune responses, it has been hypothesized that ICAM1 could function in signal transduction. ICAM1 also plays a major role in spermatogenesis due to its antagonistic effects on the tight junctions forming the blood-testis barrier. |
| Expression | ICAM1 is typically expressed on endothelial cells and cells of the immune system. ICAM1 is a type of intercellular adhesion molecule continuously present in low concentrations in the membranes of leukocytes and endothelial cells. Upon cytokine stimulation, the concentrations greatly increase. ICAM1 is also located in the vascular endothelium, macrophages, and lymphocytes. |
| Implications in Disease | ICAM1 has been implicated in subarachnoid hemorrhage (SAH). Levels of ICAM1 are shown to be significantly elevated in patients with SAH over control subjects in many studies. ICAM1 expressed by respiratory epithelial cells is also the binding site for rhinovirus, the causative agent of most common colds. ICAM1 has an important role in ocular allergies recruiting pro-inflammatory lymphocytes and mast cells promoting a type I hypersensitivity reaction. |
| Sequence Information | ICAM1 is composed of 532 amino acids with a molecular weight of 57825 Da. It contains 5 Ig-like C2-type (immunoglobulin-like) domains at positions 41 – 103, 128 – 193, 230 – 297, 325 – 378 and 412 – 464. There is a cell attachment motif at positions 152 – 154. |
| Post-Translational Modifications | ICAM1 is monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis. Glycosylation occurs at Ile60, Asn130, Asn145, Asn183, Asn202, Asn267, Asn296, Asn385 and Asn406. |
| Database Links | Entrez Gene: 3383 Human, Omim: 147840 Human, SwissProt: P05362 Human, Unigene: 643447 Human |
品牌介绍
美国Fitzgerald 公司是一家国际性知名抗体研发生产企业。Fitzgerald公司为全球试剂诊断公司与研究机构提供专业的抗体、纯化抗原以及工业诊断用大包装免疫原料。公司产品多达5000种，能够满足您对于最前沿科学研究的需求。产品涉及：单克隆抗体／抗原生育类、传染病类、TORCH系列、肿瘤标记物、心脏标记物、神经科学类、病毒类等等。
品牌分类
重组蛋白
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