Fitzgerald/CD44 antibody/10R-2062/100 ul
商品编号：
10R-2062-100ul
品牌：
fitzgerald-fii
市场价：
¥5900.00
美元价：
4425.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
OVERVIEW:
| Synonyms | MonoclonalCD44antibody,Anti-CD44antibody,H-CAMantibody,CD44antibody,CD-44,CD44,CD44,HCAMantibody,Clusterofdifferentiation44antibody,Pgp1antibody,CD-44antibody,MGC10468antibody,MDU2antibody,phagocyticglycoprotein1antibody,MDU3antibody,MIC4antibody,CSPG8antibody,LHRantibody,CD44antigenantibody,Hermesantigenantibody,INantibody |
|---|---|
| CrossReactivity | Human,Mouse |
| Applications | ELISA,FC,IF,IHC,WB |
| Immunogen | CD44antibodywasraisedinMouseusingapurifiedrecombinantfragmentofhumanCD44(628-699)expressedinE.coliastheimmunogen. |
SPECIFICATIONS:
| Host | Mouse |
|---|---|
| Clone | 8E2F3 |
| Isotype | IgG1 |
| Form&Buffer | Suppliedasaliquidinasciticfluidcontaining0.03%sodiumazide. |
| Concentration | 1.0mg/ml |
STORAGE&SAFETY:
| Storage | Storeat4degCforshorttermstorage.Storeat-20degCforlongtermstorage.Avoidrepeatedfreeze/thawcycles. |
|---|
UsageAssayInformation:
| UsageRecommendations | ELISA:1:10,000,FC:1:200-1:400,IF:1:200-1:1000,IHC:1:200-1:1000,WB:1:500-1:2000 |
|---|
GENERALINFORMATION:
| ProductUse | MonoclonalCD44antibodyspecificforHumanCD44foruseinELISA,FlowCytometry,ImmunohistochemistryandWesternBlot. |
|---|---|
| BIOLOGicalSignificance | CD44isareceptorforhyaluronicacid(HA).Mediatescell-cellandcell-matrixinteractionsthroughitsaffinityforHA,andpossIBLyalsothroughitsaffinityforotherligandssuchasosteopontin,collagens,andmatrixmetalloproteinases(MMPs).AdhesionwithHAplaysanimportantroleincellmigration,tumorgrowthandprogression.Alsoinvolvedinlymphocyteactivation,recirculationandhoming,andinhematopoiesis.Alteredexpressionordysfunctioncausesnumerouspathogenicphenotypes.Greatproteinheterogeneityduetonumerousalternativesplicingandpost-translationalmodificationevents.InteractswithPKN2.InteractswithHA,aswellasotherglycosaminoglycans,collagen,laminin,andfibronectinviaitsN-terminalsegment.InteractswithANK,theERMproteins(VIL2,RDXandMSN),andNF2viaitsC-terminalsegment.Isoform10(epithelialisoform)isexpressedbycellsofepitheliumandhighlyexpressedbycarcinomas.Expressionisrepressedinneuroblastomacells. |
| Expression | CD44isexpressedinalargenumberofmammaliancelltypes.Standardisoform,designatedCD44s,comprisingexons1–5and16–20isexpressedinmostcelltypes.CD44splicevariantscontainingvariableexonsaredesignatedCD44v.Someepithelialcellsalsoexpressalargerisoform(CD44E),whichincludesexonsv8–10.CD44islocatedintheGolgiapparatusandonthecellsurfaceintegraltoplasmamembraneaswellasthecytoplasm. |
| ImplicationsinDisease | VariationsinCD44arereportedascellsurfaceMarkersforsomebreastandprostatecancerstemcells.CD44expressioniscommonlyusedasamarkerforbreastCSCsandisusedtosortbreastcancercellsintoapopulationenrichedincellswithstem-likecharacteristics.CD44hasalsobeenusedasanindicatorofincreasedsurvivaltimeinepithelialovariancancerpatients.CD44isassociatedwithcellproliferation,celldifferentiation,cellmigration,angiogenesis,presentationofcytokines,chemokines,andgrowthfactorstothecorrespondingreceptors,anddockingofproteasesatthecellmembrane,aswellasinsignalingforcellsurvival,allattributesassociatedwiththepathologicactivitiesofcancercells. |
| SequenceInformation | CD44isamemberoftheCD44(H-CAM)familyofcellsurfaceglycoproteins.CD44contains4Hyaluronanbindingsitesataminoacids41,78,79and105. |
| Post-TranslationalModifications | CD44interactswithezrin,rADIxinandmoesin(ERM),linkingtheactinCytoskeletontotheplasmamembraneandtheECM.CD44isconstitutivelyphosphorylatedatSer325inrestingcells.ActivationofPKCresultsinphosphorylationofSer291,dephosphorylationofSer325,disassociationofezrinfromCD44,anddirectionalmotility. |
| DatabaseLinks | EntrezGene:960Human,Omim:107269Human,SwissProt:P16070Human,Unigene:502328Human |
品牌介绍
美国Fitzgerald 公司是一家国际性知名抗体研发生产企业。Fitzgerald公司为全球试剂诊断公司与研究机构提供专业的抗体、纯化抗原以及工业诊断用大包装免疫原料。公司产品多达5000种，能够满足您对于最前沿科学研究的需求。产品涉及：单克隆抗体／抗原生育类、传染病类、TORCH系列、肿瘤标记物、心脏标记物、神经科学类、病毒类等等。
品牌分类
重组蛋白
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