Fitzgerald/sAPP alpha antibody/10R-3017/100 ug
商品编号：
10R-3017-100ug
品牌：
fitzgerald-fii
市场价：
¥13500.00
美元价：
10125.00
产品分类：
单克隆抗体
公司分类：
monoclonal_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
OVERVIEW:
| Synonyms | Monoclonal sAPP alpha antibody, Anti-sAPP antibody, soluble APP alpha antibody, Mutant APP alpha antibody, soluble amyloid precursor protein alpha antibody, soluble amyloid precursor protein alpha antibody, Mutant APP alpha antibody, Mutant C-terminus APP alpha antibody, sAPP alpha antibody, soluble APP alpha antibody, Mutant C-terminus APP alpha antibody, Anti sAPP antibody |
|---|---|
| Specificity | Human |
| Cross Reactivity | Mouse, rat |
| Applications | IP, WB |
| Immunogen | Amyloid precursor protein antibody was raised in mouse using a synthetic peptide of the Cterminal part of human sAPPa (DAEFRHDSGYEVHHQK) as the immunogen |
SPECIFICATIONS:
| Host | Mouse |
|---|---|
| Clone | 2B3 |
| Isotype | IgG2b |
| Source | Supernatant |
| Method of Purification | sAPP alpha antibody was affinity purified with antigen peptide |
| Form & Buffer | Lyophilized product from 1% BSA in PBS, pH 7.4 containing 0.05% NaN3, reconstitute with 1 ml deionised water |
STORAGE & SAFETY:
| Storage | Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at 20 deg C for long term storage. Avoid repeated freeze/thaw cycles. |
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Usage Assay Information:
| Usage Recommendations | IP: 3 ug/test, WB: 25 ug/ml |
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GENERAL INFORMATION:
| Biological Significance | Amyloid precursor protein (APP) is precursor protein of Amyloid beta which is major constituent of senile plaque in Alzheimer?s disease. It is known that there are three major isoforms, APP695, APP751 and APP770, and are generated from alternative splicing of common precursor mRNA Processing of APP occurs by two major pathways, non-amyloidogenic pathway and amyloidogenic pathway.The non-amyloidogenic pathway is mediated by alpha and gamma-secretases and gives rise to a large fragment known as soluble APPalpha (sAPPalpha) and a small 3 kDa peptide known as p3. On the other hand, the Amyloidogenic pathway is mediated by beta and gamma secretases and yields soluble APPbeta (sAPPbeta) and Amyloid beta. APP is expressed by many tissues within an organism. It is supposed that the function of APP in the neuronal system is different from that in other organs. |
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品牌介绍
美国Fitzgerald 公司是一家国际性知名抗体研发生产企业。Fitzgerald公司为全球试剂诊断公司与研究机构提供专业的抗体、纯化抗原以及工业诊断用大包装免疫原料。公司产品多达5000种，能够满足您对于最前沿科学研究的需求。产品涉及：单克隆抗体／抗原生育类、传染病类、TORCH系列、肿瘤标记物、心脏标记物、神经科学类、病毒类等等。
品牌分类
重组蛋白
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