菲茨杰拉德/SOCS3抗体/10R-3023/200微克
商品编号：
10R-3023-200ug
品牌：
fitzgerald-fii
市场价：
¥13500.00
美元价：
10125.00
产品分类：
单克隆抗体
公司分类：
monoclonal_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
OVERVIEW:
| Synonyms | Monoclonal SOCS antibody, Anti-SOCS3 antibody, SOCS-3 antibody, CIS3 antibody, ATOD4 antibody, SOCS 3 antibody, Cytokine-inducible SH2 protein 3 antibody, SOCS3, SOCS-3, SOCS 3, STAT-induced STAT inhibitor 3 antibody |
|---|---|
| Specificity | Human |
| Applications | WB |
| Immunogen | Janus antibody was raised in mouse using a synthetic peptide corresponding to the Cterminal part of human CIS3/SOCS3 as the immunogen |
SPECIFICATIONS:
| Host | Mouse |
|---|---|
| Clone | 19A5 |
| Isotype | IgG1 |
| Source | Supernatant |
| Method of Purification | SOCS3 antibody was affinity purified with antigen peptide |
| Form & Buffer | Lyophilized product from 1 % BSA in PBS, pH 7.4 containing 0.05 % NaN3, reconstitute with 1 ml of deionised water |
STORAGE & SAFETY:
| Storage | Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at 20 deg C for long term storage. Avoid repeated freeze/thaw cycles. |
|---|
Usage Assay Information:
| Usage Recommendations | WB: 15 ug/ml |
|---|
GENERAL INFORMATION:
| Biological Significance | The Janus family of protein tyrosine kinases (JAKs) and STAT transcription factors regulate cellular processes involved in cell growth, differentiation, and transformation through their association with cytokine receptors. The CIS family of proteins (also referred as the SOCS or SSI family) has been implicated in the regulation of signal transduction by a variety of cytokines. The cytokine-inducible SH2 protein 3 (CIS3/SOCS3/SSI3) has been shown to inhibit the JAK/STAT pathway and act as a negative regulator of fetal liver erythropoiesis. Recently, it is reported that CIS3 regulates the erythropoietin (EPO) receptor (EPOR) signaling in erythroid progenitors and Ba/F3 cells expressing the EPOR (BFER). CIS3 binds directly to the EPOR as well as JAK2 and inhibits EPOdependent proliferation and STAT5 activation. It is reported that JAB/SOCS1 is strongly induced by interferongamma and forced expression of JAB/SOCS1 conferred cells interferon resistance. This resistance was caused by inhibition of JAK1 and JAK2 activation in response to IFN gamma. Moreover, recent detailed analysis of JAB/SOCS1 knockout mice revealed that JAB/SOCS1 is indeed a "negative feedback regulator" that determines the sensitivity of cells to IFN gamma. |
|---|
品牌介绍
美国Fitzgerald 公司是一家国际性知名抗体研发生产企业。Fitzgerald公司为全球试剂诊断公司与研究机构提供专业的抗体、纯化抗原以及工业诊断用大包装免疫原料。公司产品多达5000种，能够满足您对于最前沿科学研究的需求。产品涉及：单克隆抗体／抗原生育类、传染病类、TORCH系列、肿瘤标记物、心脏标记物、神经科学类、病毒类等等。
品牌分类
重组蛋白
联络我们
