Fitzgerald/Presenilin 1 antibody/10R-3064/200 ug
商品编号：
10R-3064-200ug
品牌：
fitzgerald-fii
市场价：
¥13500.00
美元价：
10125.00
产品分类：
单克隆抗体
公司分类：
monoclonal_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
OVERVIEW:
| Synonyms | Monoclonal Presenilin 1 antibody, Anti-Presenilin 1 antibody, PS1 antibody, Presenilin-1, Presenilin-1 antibody, Presenilin 1, Presenilin 1 antibody, PS-1 antibody, Presenilin 1, Presenilin-1 antibody |
|---|---|
| Specificity | Human |
| Cross Reactivity | Top be determined by end-user |
| Applications | IHC, WB |
| Immunogen | Presenilin 1 antibody was raised in mouse using the Nterminal fragment of recombinant human Presenilin1 (E. coli) as the immunogen |
SPECIFICATIONS:
| Host | Mouse |
|---|---|
| Clone | 17C2 |
| Isotype | IgG1 |
| Source | Supernatant |
| Method of Purification | Presenilin 1 antibody was affinity purified with protein A |
| Form & Buffer | Lyophilized product from 1% BSA in PBS containing 0.05% NaN3, reconstitute with 1 ml of distilled water |
STORAGE & SAFETY:
| Storage | Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at 20 deg C for long term storage |
|---|
Usage Assay Information:
| Usage Recommendations | IHC: 10 ug/ml, WB: 5 ug/ml |
|---|
GENERAL INFORMATION:
| Biological Significance | The presenilin 1 (PS1) gene was identified as the gene that harbors mutations that cause this type of FAD (termed AD3). PS1 is a novel 467aa long integral membrane protein localized to intracellular membranous compartments, especially the endoplasmic reticulum, that spans the membrane 79 times. More than 30 missense mutations or amino acid deletions have been identified in a number of AD3 pedigrees. Shortly after the discovery of PS1, the gene responsible for FAD was found on chromosome 1. This gene is known as PS2 and it is highly homologous to PS1 (67% identical). Sequence analysis predicts integral membrane proteins, which contain seven putative transmembrane domains, a short hydrophilic amino and C-terminal tail, and a large hydrophilic loop between the sixth and seventh membrane-spanning domains. All of the reported mutations that result in early-onset Alzheimer?s disease are missense mutations, 24 in PS1 and two in PS2, or mutations that affect the splicing without affecting the coding of the protein and this has led to the hypothesis that they may result in a gain of (miss) function. |
|---|
品牌介绍
美国Fitzgerald 公司是一家国际性知名抗体研发生产企业。Fitzgerald公司为全球试剂诊断公司与研究机构提供专业的抗体、纯化抗原以及工业诊断用大包装免疫原料。公司产品多达5000种，能够满足您对于最前沿科学研究的需求。产品涉及：单克隆抗体／抗原生育类、传染病类、TORCH系列、肿瘤标记物、心脏标记物、神经科学类、病毒类等等。
品牌分类
重组蛋白
联络我们
