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当前位置: 首页 > 产品中心 > monoclonal_antibody > Fitzgerald/Neticulocalbin 1抗体/10R-3066/50微克
商品详细Fitzgerald/Neticulocalbin 1抗体/10R-3066/50微克
Fitzgerald/Neticulocalbin 1抗体/10R-3066/50微克
Fitzgerald/Neticulocalbin 1抗体/10R-3066/50微克
商品编号: 10R-3066-50ug
品牌: fitzgerald-fii
市场价: ¥13900.00
美元价: 10425.00
产地: 美国(厂家直采)
公司:
产品分类: 单克隆抗体
公司分类: monoclonal_antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍

OVERVIEW:

Synonyms Monoclonal Reticulocalbin 1 antibody, Anti-Reticulocalbin 1 antibody, EF-hand Calcium binding Domain Pseudogene 2 antibody, RCN 1 antibody, RCN 1, RCN-1, RCN1, RCN-1 antibody
Specificity Human
Cross Reactivity To be determined by end-user
Applications IHC, IP, WB
Immunogen Reticulocalbin1 antibody was raised in mouse using recombinant protein of the Cterminal site (90 aa) of human Reticulocalbin1 as the immunogen

SPECIFICATIONS:

Host Mouse
Clone TMU6A1
Isotype IgG1
Source Supernatant
Method of Purification Reticulocalbin 1 antibody was affinity purified with protein A
Form & Buffer Lyophilized product from 1% BSA in PBS containing 0.05% NaN3, reconstitute in 1 ml of deionised water

STORAGE & SAFETY:

Storage Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at 20 deg C for long term storage

Usage Assay Information:

Usage Recommendations IHC: 0.055 ug/ml, IP: 3 ug/test, WB: 15 ug/ml

GENERAL INFORMATION:

Biological Significance Human Reticulocalbin 1 is a 44kDa protein and belongs to the EF (elongation factor) and calcium binding protein family, and it is known as a luminal protein of endoplasmic reticulum (ER) with the C-terminal HDEL (ER retention signal) sequence. Although it is known that the protein contains six repeated domains each of which has an EF-hand motif, the function of them has not been clalified clearly. In analysis of tumor cells, higher expression of Reticulocalbin 1 is reported in hepatocellular carcinoma than normal hepatocytes and the study suggests the possibility of its involvement in malignancy of human cells through calcium regulation, but there are few reports regarding the expression of Reticulocalbin 1 in oncology. One study reports that Reticulocalubin1 has been found to be highly expressed in cultured cells of highly invasive breast cancer, while it has not been found in low invasive cells, however, its significance is not altogether clear. One of the anticancer drugs most commonly used is cisplatin. Currently, cisplatin (cisdiamminedichloroplatinum (II); cisDDP) is a principal drug of cancer chemotherapy, and it shows beneficial effects in some solid cancers such as head and neck cancer, testicular tumor, ovary cancer and smallcell lung cancer. Hirano et al. reported that in research of markers of anticancer drug sensitivity, they compared the protein expression of cisplatinresistant cell strains and its parent strains using twodimensional electrophoresis and found a spot which was markedly decreased in expression, and then, the analysis of amino acid sequence showed that the spot was Reticulocalbin1.
品牌介绍
美国Fitzgerald 公司是一家国际性知名抗体研发生产企业。Fitzgerald公司为全球试剂诊断公司与研究机构提供专业的抗体、纯化抗原以及工业诊断用大包装免疫原料。公司产品多达5000种,能够满足您对于最前沿科学研究的需求。产品涉及:单克隆抗体/抗原生育类、传染病类、TORCH系列、肿瘤标记物、心脏标记物、神经科学类、病毒类等等。