Fitzgerald/Tob antibody/10R-3077/200 ug
商品编号：
10R-3077-200ug
品牌：
fitzgerald-fii
市场价：
¥13500.00
美元价：
10125.00
产品分类：
单克隆抗体
公司分类：
monoclonal_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
OVERVIEW:
| Synonyms | MonoclonalTobantibody,Anti-Tobantibody,PIG49antibody,PIG49antibody,ProteinTob1antibody,AntiTobantibody,ProteinTob1antibody,TROBantibody,Tobantibody,TROBantibody,APRO6antibody,APRO6antibody |
|---|---|
| CrossReactivity | Tobedeterminedbyend-user |
| Applications | IHC,WB |
| Immunogen | TobantibodywasraisedinmouseusingrecombinantTob(E.coli)astheimmunogen |
SPECIFICATIONS:
| Host | Mouse |
|---|---|
| Clone | 4B1 |
| Isotype | IgG2a |
| Source | Supernatant |
| MethodofPurification | TobantibodywasaffinitypurifiedwithproteinA |
| Form&Buffer | Lyophilizedproductfrom1%BSAinPBScontaining0.05%NaN3,reconstitutewith1mlofdistilledwater |
STORAGE&SAFETY:
| Storage | Storeat4degCuntilreconstitution.Followingreconstitutionaliquotandfreezeat20degCforlongtermstorage |
|---|
UsageAssayInformation:
| UsageRecommendations | IHC:13ug/ml,WB:1ug/ml |
|---|
GENERALINFORMATION:
| BIOLOGicalSignificance | ACDNAforanovelproteintermedTob(TransducerofErbB2)thatinteractswiththecerbB2geneproductp185erbB2wasmolecularlycloned.NucleotidesequencingrevealsthattheTobproteinisa45kDaproteinthatdoesnotcontaineitherSH2orSH3domainbutishomologoustothepreviouslycharacterizedantiproliferativegeneproductBTG1atitsaminoterminalhalf.ThecarboxylterminalhalfofTobischaracterizedbythepresenceofasequencerichinprolineandglutamineandshowsnohomologytoknownproteins.LikeBTG1,exogenouslyexpressedTobisabletosuppressgrowthofNIH3T3cells,butthegrowthsuppressionishamperedbythepresenceofkinaseactivep185erbB2.ByusingtheSGTTobproteinthatcontainseitherfulllengthoraminoterminalhalfofTob,ThecarboxylterminalhalfofTobisrelevanttoitsinteractionwithp185erbB2.Inaddition,coimmunoprecipitationoftheTobproteinwithantiErbB2antibodyandreciprocallythep185erbB2withantiTobantibodiescouldbeconducted.Thesedatasuggestthatp185erbB2negativelyregulatestheTob-mediatedantiproliferativepathwaythroughitsinteractionwithTob.TheexpressionoftheTobmRNAisobservedinvariouscelltypesandisnotcorrelatedwithexpressionofcerbB2,suggestingthatotherreceptor-typeproteintyrosinekinasesarealsoinvolvedtheTob-mediatedregulationofcellgrowth. |
|---|
品牌介绍
美国Fitzgerald 公司是一家国际性知名抗体研发生产企业。Fitzgerald公司为全球试剂诊断公司与研究机构提供专业的抗体、纯化抗原以及工业诊断用大包装免疫原料。公司产品多达5000种，能够满足您对于最前沿科学研究的需求。产品涉及：单克隆抗体／抗原生育类、传染病类、TORCH系列、肿瘤标记物、心脏标记物、神经科学类、病毒类等等。
品牌分类
重组蛋白
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