Fitzgerald/SETD7 antibody/10R-5754/100 ul
商品编号：
10R-5754-100ul
品牌：
fitzgerald-fii
市场价：
¥12240.00
美元价：
9180.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
OVERVIEW:
| Synonyms | Monoclonal SETD7 antibody, Anti-SETD7 antibody, SET domain containing ( lysine methyltransferase) 7 antibody, FLJ21193 antibody, KIAA1717 antibody, KMT7 antibody, SET7 antibody, SETD7, SETD 7, SETD-7, SETD 7 antibody, SETD-7 antibody |
|---|---|
| Cross Reactivity | Human |
| Applications | FC, WB |
| Immunogen | SETD7 antibody was raised in mouse using a full length recombinant protein of human SETD7 (NP_085151) produced in HEK293T cells, as the immunogen. |
SPECIFICATIONS:
| Host | Mouse |
|---|---|
| Clone | 5B11 |
| Isotype | IgG2a |
| Method of Purification | SETD7 antibody was purified by affinity chromatography. |
| Form & Buffer | Supplied in PBS buffer, pH 7.3, containing 1% BSA, 50% glycerol and 0.02% sodium azide. |
| Concentration | 500 ug-1 mg/ml |
STORAGE & SAFETY:
| Storage | Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles. |
|---|
Usage Assay Information:
| Usage Recommendations | FC: 1:100, WB: 1:500 |
|---|
GENERAL INFORMATION:
| Biological Significance | This gene encodes a histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. Also able to demethylated 'Lys-372' of p53/TP53 in vitro. |
|---|
品牌介绍
美国Fitzgerald 公司是一家国际性知名抗体研发生产企业。Fitzgerald公司为全球试剂诊断公司与研究机构提供专业的抗体、纯化抗原以及工业诊断用大包装免疫原料。公司产品多达5000种，能够满足您对于最前沿科学研究的需求。产品涉及：单克隆抗体／抗原生育类、传染病类、TORCH系列、肿瘤标记物、心脏标记物、神经科学类、病毒类等等。
品牌分类
重组蛋白
联络我们
