Fitzgerald/WWTR1 antibody/10R-6288/100 ul
商品编号：
10R-6288-100ul
品牌：
fitzgerald-fii
市场价：
¥7900.00
美元价：
5925.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
OVERVIEW:
| Synonyms | Monoclonal WWTR1 antibody, Anti-WWTR1 antibody, WW domain containing transcription regulator 1 antibody, TAZ antibody, DKFZp586I1419 antibody, Transcriptional coactivator with PDZ-binding motif antibody, FLJ45718 antibody, WW domain-containing transcription regulator protein 1 antibody, WWTR1, WWTR 1, WWTR-1, WWTR 1 antibody, WWTR-1 antibody |
|---|---|
| Cross Reactivity | Human |
| Applications | FC, IF, WB |
| Immunogen | WWTR1 antibody was raised in mouse using a full length recombinant protein of human WWTR1 (NP_056287) produced in HEK293 cell as the immunogen. |
SPECIFICATIONS:
| Host | Mouse |
|---|---|
| Clone | 1B5 |
| Isotype | IgG1 |
| Method of Purification | WWTR1 antibody was purified by affinity chromatography. |
| Form & Buffer | Supplied in PBS buffer, pH 7.3, containing 1% BSA, 50% glycerol and 0.02% sodium azide. |
| Concentration | 500 ug-1 mg/ml |
STORAGE & SAFETY:
| Storage | Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles. |
|---|
Usage Assay Information:
| Usage Recommendations | FC: 1:100, IF: 1:100, WB: 1:200-500 |
|---|
GENERAL INFORMATION:
| Biological Significance | WWTR1 is a transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylatesand in activates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. |
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品牌介绍
美国Fitzgerald 公司是一家国际性知名抗体研发生产企业。Fitzgerald公司为全球试剂诊断公司与研究机构提供专业的抗体、纯化抗原以及工业诊断用大包装免疫原料。公司产品多达5000种，能够满足您对于最前沿科学研究的需求。产品涉及：单克隆抗体／抗原生育类、传染病类、TORCH系列、肿瘤标记物、心脏标记物、神经科学类、病毒类等等。
品牌分类
重组蛋白
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