Fitzgerald/p53 antibody/10R-6721/100 ug
商品编号：
10R-6721-100ug
品牌：
fitzgerald-fii
市场价：
¥11500.00
美元价：
8625.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
OVERVIEW:
| Synonyms | Monoclonalp53antibody,Anti-p53antibody,p53Oncoproteinantibody,p53,p53,p-53,p53antibody,p-53antibody |
|---|---|
| CrossReactivity | Human,Mouse,Rat |
| Applications | ICC,IHC,IP,WB |
| Immunogen | p53antibodywasraisedinMouseusingsyntheticpeptidecorrespondingtoresiduesurroundingaminoacid375ofhumanp53astheimmunogen. |
SPECIFICATIONS:
| Host | Mouse |
|---|---|
| Clone | C6A5 |
| Isotype | IgG1 |
| MethodofPurification | p53antibodywaspurifiedbyaffinitypurification. |
| Form&Buffer | SuppliedinPBSbuffer,pH7.2,containing30%glycerol,0.5%BSA,0.01%thimerosal. |
| Concentration | 500ug/ml |
STORAGE&SAFETY:
| Storage | Storeat-20degC.Forlong-termstorage,aliquotandfreezeat-70degC.Avoidrepeatedfreeze/thawcycles. |
|---|
UsageAssayInformation:
| UsageRecommendations | ICC:4-8ug/ml,IP:4-8ug/ml,IHC:4-8ug/ml,WB:0.5-4ug/ml |
|---|
GENERALINFORMATION:
| BIOLOGicalSignificance | p53,a53kDaprotein,bindstoaDNAconsensussequence,thep53responseelement,andregulatesnormalcellcycleeventsbyactivatingtranscriptionofgenesinvolvedeitherinprogressionthroughthecellcycle,orcausingarrestinG1whenthegenomeisdamaged.Inmosttransformedandtumorcellstheconcentrationofp53isincreased51000foldovertheconcentrationinnormalcells,principallyduetotheincreasedhalflife(4hrs)comparedtothatofwildtype(20min).p53localizesinthenucleus,butisdetectableattheplasmamembraneduringmitosisandcertainmutationsalsomodulatecytoplasmic/nucleardistribution.p53downregulatesBcl2expressionandupregulatesBaxexpression,butmaynotalwaysbenecessaryforapoptosis. |
|---|
品牌介绍
美国Fitzgerald 公司是一家国际性知名抗体研发生产企业。Fitzgerald公司为全球试剂诊断公司与研究机构提供专业的抗体、纯化抗原以及工业诊断用大包装免疫原料。公司产品多达5000种，能够满足您对于最前沿科学研究的需求。产品涉及：单克隆抗体／抗原生育类、传染病类、TORCH系列、肿瘤标记物、心脏标记物、神经科学类、病毒类等等。
品牌分类
重组蛋白
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