Fitzgerald/IL23 antibody/10R-6640/25 ug
商品编号：
10R-6640-25ug
品牌：
fitzgerald-fii
市场价：
¥2800.00
美元价：
2100.00
产品分类：
多克隆抗体
公司分类：
Polyclonal_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
OVERVIEW:
| Synonyms | MonoclonalIL23antibody,Anti-IL23antibody,(Interleukin-23subunitp19antibody,IL-23antibody,Interleukin-23p19Interleukin-23subunitalphaantibody,IL-23p19antibody,IL-23,IL23,IL23antibody,IL-23subunitalphaantibody,IL-23-Aantibody,IL23 |
|---|---|
| Specificity | Mouse |
| Applications | FC,IP,WB |
| AssayInformation | Atestisdefinedastheamount(ug)ofantibodythatwillstainacellsampleinafinalvolumeof100ul.Cellnumbershouldbedeterminedempiricallybutcanrangefrom105to108cells/test.Itisrecommendedthattheantibodybecarefullytitratedforoptimal/formanceintheassayofinterest |
SPECIFICATIONS:
| Host | Mouse |
|---|---|
| Clone | 473P19 |
| Isotype | IgG1kappa |
| MethodofPurification | IL23antibodywaspurifiedbyaffinitychromatography. |
| Form&Buffer | Suppliedinaqueousbufferwith0.09%sodiumazide,maycontaincarrierprotein/stABIlizer. |
| Concentration | 500ug/ml |
STORAGE&SAFETY:
| Storage | Storeat2-8degC.Donotfreeze.Protectfromlight. |
|---|
UsageAssayInformation:
| UsageRecommendations | FC:=0.5ug/test |
|---|
GENERALINFORMATION:
| BIOLOGicalSignificance | The473P19antibodyreactswiththep19subunitofhumanIL-23.The473P19antibodywasgeneratedfromimmunizationwithauthentic,insectcell-expressed,recombinanthumanIL-23heterodimer.Theuseofap19-specificcaptureantibodyandap40-specificdetectionantibodyyieldsahumanIL-23sandwichELISAexquisitelyspecificforhumanIL-23.IL-12p40monomerandIL-12p70wererunintheassayat200ng/mlwithnointerferenceorcross-reactivityobserved.Apanelof20unrelatedcytokineswasalsorunintheIL-23ELISAat100ng/mlwithnocrossreactivityobserved.TheassayhasbeenvalidatedbyspecificdetectionofsignificantlevelsofnativehumanIL-23proteininsupernatantsfromavarietyofdifferentactivateddendriticcellpopulations.IL-23isaheterodimericcytokinecomposedofthep40subunitofIL-12disulfide-linkedwithaproteinp19.p19,likep35ofIL-12,isbiologicallyinactivebyitself.IL-23interactswithIL-12Rbeta1andanadditional,novelbeta2-likereceptorsubunitwithSTAT4bindingdomain,termedIL-23R.IL-23issecretedbyactivatedmouseandhumandendriticcells.BiologicalactivitiesofmouseIL-23aredistinctfromthoseofmouseIL-12.MouseIL-23wasfoundnottoinducesignificantamountsofIFN-g.MouseIL-23doesinducestrongproliferationofmemoryTcells,whereasIL-12hasnoeffectonmemorycells.Additionally,mouseIL-23canactivatemousememoryTcellstoproducetheproinflammatorycytokineIL-17.HumanIL-23hasbiologicalpropertieswhicharelessdistinctfromhumanIL-12humanIL-23inducesproliferationofmemoryTcellsandinducesmoderatelevelsofIFN-gproductionbynaïveandmemoryTcells,ascomparedtoIL-12.IL-23-dependent,IL-17-producingCD4+TcellshavebeenidentifiedasauniquesubsetofThcellsthatdevelopsalongapathwaythatisdistinctfromtheTh1-andTh2-celldifferentiationpathways.ThehallmarkeffectormoleculesofTh1andTh2cells,e.g.,IFN-gandIL-4,haveeachbeenfoundtonegativelyregulatethegenerationoftheseTh-17cells.Morerecently,denovodifferentiationofTh-17cellsintheabsenceofIL-23hasbeendemonstratedbytreatmentofnaïveCD4cellswithTGF-beta1andIL-6. |
|---|
品牌介绍
美国Fitzgerald 公司是一家国际性知名抗体研发生产企业。Fitzgerald公司为全球试剂诊断公司与研究机构提供专业的抗体、纯化抗原以及工业诊断用大包装免疫原料。公司产品多达5000种，能够满足您对于最前沿科学研究的需求。产品涉及：单克隆抗体／抗原生育类、传染病类、TORCH系列、肿瘤标记物、心脏标记物、神经科学类、病毒类等等。
品牌分类
重组蛋白
联络我们
