Fitzgerald/Myc Tag antibody/10R-7790/500 ug
商品编号：
10R-7790-500ug
品牌：
fitzgerald-fii
市场价：
¥9900.00
美元价：
7425.00
产品分类：
多克隆抗体
公司分类：
Polyclonal_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
OVERVIEW:
| Synonyms | MonoclonalMycTagantibody,Anti-MycTagantibody |
|---|---|
| Specificity | Humanc-myc |
| Applications | WB |
| Immunogen | MycTagantibodywasraisedinMouseusingSyntheticpeptidesastheimmunogen. |
SPECIFICATIONS:
| Host | Mouse |
|---|---|
| Clone | NYRhc-myc |
| Isotype | IgG1a |
| MethodofPurification | MycTagantibodywaspurifiedbyProteinAaffinitychromatography |
| Form&Buffer | Suppliedinlyophilizedform,reconstituteinsterileH2OorPBSbuffer |
STORAGE&SAFETY:
| Storage | Storeat4degCforshorttermstorage.Forlongtermstoragealiquotandstoreat-20degC,avoidrepeatedfreeze/thawcycles. |
|---|
UsageAssayInformation:
| UsageRecommendations | WB:1:2000 |
|---|
GENERALINFORMATION:
| ProductUse | MonoclonalMycTagantibodyspecificforHumancMycforuseinWesternBlot. |
|---|---|
| BIOLOGicalSignificance | cMycisaproto-oncogenictranscriptionfactorthatplaysaroleincellproliferation,apoptosisandinthedevelopmentofhumantumors.Mycseemstoactivatethetranscriptionofgrowth-relatedgenesandalsofunctionsincelldifferentiationandneoplasticdisease.Mycproteinsarenuclearproteinswithrelativelyshorthalflives. |
| Expression | Mycisexpressedinalmostallproliferatingcellsinembryonicandadulttissues;inadulttissues,expressioncorrelateswithcellproliferation;abnormallyhighexpressionisfoundinawidevarietyofhumanandrodenttumours.Mycislocatedpredominantlyinthenucleus. |
| ImplicationsinDisease | Amplificationofthec-Mycgenehasbeenfoundinseveraltypesofhumantumorsincludinglung,breastandcoloncarcinomas,whiletheN-Mycgenehasbeenfoundamplifiedinneuroblastomas.c-Mychasbeenreportedtobeamplifiedandexpressedathighlevelinhumansmallcelllungcarcinomas.DefectsinMYCarealsoacauseofBurkittlymphoma,aformofundifferentiatedmalignantlymphomacommonlymanifestedasalargeosteolyticlesioninthejaworasanaBDominalmass. |
| SequenceInformation | MycproteinbelongstoMycfamilyoftranscriptionfactors,whichalsoincludesN-MycandL-Mycgenes.MycfamilyoftranscriptionfactorscontainbHLH/LZ(basicHelix-Loop-HelixLeucineZipper)domain.Mycprotein,throughitsbHLHdomaincanbindtoDNA,whiletheleucinezipperdomainallowsthedimerizationwithitspartnerMax,anotherbHLHtranscriptionfactor.Myccontains39aminoacidsand48kDainthep64;454aminoacidsinthep67(15additionalaminoacidsinN-term;containsfromN-termtoC-term:atransactivationdomain,anacidicdomain,anuclearlocalizationsignal,abasicdomain,anhelix-loop-helixmotif,andaleucinzipper;DNAbindingprotein |
| Post-TranslationalModifications | Thepresenceofthreesequencemotifsinthec-MycCOOHterminus,includingtheleucinezipper,thehelix-loop-helixandabasicregionprovidedinitialevidenceforasequence-specificbindingfunction.Abasicregionhelix-loop-helixleucinezippermotif(bHLH-Zip)protein,designatedMax,specificallyassociateswithc-Myc,N-MycandL-Mycproteins.TheMyc-MaxcomplexbindstoDNAinasequence-specificmannerunderconditionswhereneitherMaxnorMycexhibitappreciablebinding.MaxcanalsoformheterodimerswithatleasttwoadditionalbHLH-Zipproteins,MadandMxi1,andMad-MaxdimershavebeenshowntorepresstranscriptionthroughinteractionwithmSin3. |
| DatabaseLinks | EntrezGene:5420Human,Omim:602632Human,SwissProt:O00592Human,Unigene:732423Human |
品牌介绍
美国Fitzgerald 公司是一家国际性知名抗体研发生产企业。Fitzgerald公司为全球试剂诊断公司与研究机构提供专业的抗体、纯化抗原以及工业诊断用大包装免疫原料。公司产品多达5000种，能够满足您对于最前沿科学研究的需求。产品涉及：单克隆抗体／抗原生育类、传染病类、TORCH系列、肿瘤标记物、心脏标记物、神经科学类、病毒类等等。
品牌分类
重组蛋白
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