菲茨杰拉德/CDK4抗体/10R-7838/100微克
商品编号：
10R-7838-100ug
品牌：
fitzgerald-fii
市场价：
¥5400.00
美元价：
4050.00
产品分类：
多克隆抗体
公司分类：
Polyclonal_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
OVERVIEW:
| Synonyms | MonoclonalCDK4antibody,Anti-CDK4antibody,Celldivisionproteinkinase4antibody,CMM3antibody,Crk3antibody,CMM3antibody,p34cdk4antibody,CDK4,CDK4,PSKJ3antibody,MGC14458antibody,Cyclindependentkinase4antibody,CDK-4,CDK4antibody,CDK-4antibody,Cyclin-dependentkinase4antibody,Celldivisionkinase4antibody,PSK-J3antibody,Melanomacutaneousmalignant3antibody |
|---|---|
| Applications | ICC,WB |
| Immunogen | CDK4antibodywasraisedinmouseusingrecombinanthumanCdk4proteinastheimmunogen |
SPECIFICATIONS:
| Host | Mouse |
|---|---|
| Clone | IML-4 |
| Isotype | IgG2a |
| Form&Buffer | Suppliedinlyophilizedform |
STORAGE&SAFETY:
| Storage | Storeat4degCforshorttermstorage.Forlongtermstoragealiquotandstoreat-20degC,avoidrepeatedfreeze/thawcycles. |
|---|
UsageAssayInformation:
| UsageRecommendations | Optimalconditionstobedeterminedbytheenduser |
|---|
GENERALINFORMATION:
| BIOLOGicalSignificance | Cyclin-dependentkinaseactivityisregulatedbyT-loopphosphorylation,bytheabundanceoftheircyclinpartnersandbyassociationwithCDKinhibitorsoftheCip/KiporINKfamilyofproteins.TheinactiveternarycomplexofCDK4/cyclinDandp27Kip1/Cip1requiresextracellularmitogenicstimuliforthereleaseanddegradationofp27,whichaffectsprogressionthroughtherestrictionpointandpRb-dependententryintoS-phase.TheactivecomplexofCDK4/cyclinDtargetstheretinoblastomaproteinforphosphorylation,allowingthereleaseofE2FtranscriptionfactorsthatactivateG1/S-phasegeneexpression.InHeLacells,uponUVirrADIation,upregulationofp16INK4aassociationwithCDK4/cyclinD3leadstoaG2delay,implicatingCDK4/cyclinD3activityinprogressionthroughG2-phaseofthecellcycle. |
|---|
品牌介绍
美国Fitzgerald 公司是一家国际性知名抗体研发生产企业。Fitzgerald公司为全球试剂诊断公司与研究机构提供专业的抗体、纯化抗原以及工业诊断用大包装免疫原料。公司产品多达5000种，能够满足您对于最前沿科学研究的需求。产品涉及：单克隆抗体／抗原生育类、传染病类、TORCH系列、肿瘤标记物、心脏标记物、神经科学类、病毒类等等。
品牌分类
重组蛋白
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