菲茨杰拉德/帕西林抗体/10R-7891/100微克
商品编号：
10R-7891-100ug
品牌：
fitzgerald-fii
市场价：
¥5400.00
美元价：
4050.00
产品分类：
多克隆抗体
公司分类：
Polyclonal_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
OVERVIEW:
| Synonyms | MonoclonalPaxillinantibody,Anti-Paxillinantibody,Paxillinantibody,PXNantibody,PXNantibody,AntiPaxillinantibody |
|---|---|
| Applications | ICC,WB |
| Immunogen | PaxillinantibodywasraisedinmouseusingC-terminalpartofrecombinantchickenpaxillin(aminoacids305-559)astheimmunogen |
SPECIFICATIONS:
| Host | Mouse |
|---|---|
| Clone | PAX-14 |
| Isotype | IgG1 |
| Form&Buffer | Suppliedinlyophilizedform |
STORAGE&SAFETY:
| Storage | Storeat4degCforshorttermstorage.Forlongtermstoragealiquotandstoreat-20degC,avoidrepeatedfreeze/thawcycles. |
|---|
UsageAssayInformation:
| UsageRecommendations | Optimalconditionstobedeterminedbytheenduser |
|---|
GENERALINFORMATION:
| ProductUse | MonoclonalPXNantibodyspecificforHumanPXNforuseinWesternBlotandImmunocytochemistry. |
|---|---|
| BIOLOGicalSignificance | Paxillin(PXN)isasignaltransductionadaptorprotein.TheC-terminalregionofpaxillincontainsfourLIMdomainsthattargetpaxillintofocaladhesions.Itispresumedthroughadirectassociationwiththecytoplasmictailofbeta-integrin.TheN-terminalregionofpaxillinisrichinprotein–proteininteractionsites.Theproteinsthatbindtopaxillinarediverseandincludeproteintyrosinekinases,suchasSrcandfocaladhesionkinase(FAK),structuralproteins,suchasvinculinandactopaxin,andregulatorsofactinorganization,suchasCOOL/PIXandPKL/GIT. |
| Expression | ElevatedPXNexpressionhasbeenreportedinseveralhumancarcinomasinparticularbreastcancer.PXNisfoundmostlyinthecytoplasmandisconcentratedatfocaladhesionjunctions. |
| ImplicationsinDisease | Paxillinandcortactinhavebeenshowntocolocalizeatinvadopodiaandplayapivotalroleinbreastcancerinvasion.SimilarcolocalizationofPXNhasbeenobservedincorectalcancer. |
| SequenceInformation | PXNiscomposedof591aminoacidswithamolecularweightof64505Da.Thereare5LDmotifsatpositions3–15,144–156,216–228,265–276and333–345and4LIMzinc-bindingdomainsat356–415,416–473,474–533and534–591. |
| Post-TranslationalModifications | PXNisPhosphorylatedbyMAPK1/ERK2.PhosphorylationatTyr-31andTyr-118byPTK6promotetheactivationofRAC1viaCRK/CrKII,therebypromotingmigrationandinvasion. |
| DatabaseLinks | EntrezGene:5829Human,Omim:602505Human,SwissProt:P49023Human,Unigene:446336Human |
品牌介绍
美国Fitzgerald 公司是一家国际性知名抗体研发生产企业。Fitzgerald公司为全球试剂诊断公司与研究机构提供专业的抗体、纯化抗原以及工业诊断用大包装免疫原料。公司产品多达5000种，能够满足您对于最前沿科学研究的需求。产品涉及：单克隆抗体／抗原生育类、传染病类、TORCH系列、肿瘤标记物、心脏标记物、神经科学类、病毒类等等。
品牌分类
重组蛋白
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