菲茨杰拉德/CD274抗体/10R-8058/100微克
商品编号：
10R-8058-100ug
品牌：
fitzgerald-fii
市场价：
¥3900.00
美元价：
2925.00
产品分类：
多克隆抗体
公司分类：
Polyclonal_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
OVERVIEW:
| Synonyms | MonoclonalCD274antibody,Anti-CD274antibody,PDCD1L1antibody,PDCD1LG1antibody,PDL1antibody,CD274antibody,CD-274antibody,CD274,CD-274,CD274,B7-Hantibody,B7H1antibody,PD-L1antibody |
|---|---|
| Applications | FC,IHC-F,IP |
| Immunogen | CD274antibodywasraisedinRatusingMouseCD274transfectedL5178Ycellsastheimmunogen |
SPECIFICATIONS:
| Host | Rat |
|---|---|
| Clone | MIH6 |
| Isotype | IgG2a |
| MethodofPurification | CD274antibodywaspurifiedbyProteinGaffinitychromatography |
| Form&Buffer | SuppliedinPBSbufferwith0.09%SodiumAzide(NaN3)addedasapreservative |
| Concentration | 1.0mg/ml |
STORAGE&SAFETY:
| Storage | Storeat4degCforshorttermstorageoraliquotandfreezeat-20degCforlongtermstorage |
|---|
UsageAssayInformation:
| UsageRecommendations | FC,IHC-F,IP |
|---|
GENERALINFORMATION:
| ProductUse | MonoclonalCD274antibodyspecificforHumanCD274foruseinFlowCytometry,ImmunohistochemistryandImmunoprecipitation. |
|---|---|
| BIOLOGicalSignificance | CD274isatransmembraneproteinthathasbeenspeculatedtoplayamajorroleinsuppressingtheimmunesystemduringparticulareventssuchaspregnancy,tissueallografts,autoimmunediseaseandotherdiseasestatessuchashepatitis.Normallytheimmunesystemreactstoforeignantigenswherethereissomeaccumulationinthelymphnodesorspleenwhichtriggersaproliferationofantigen-specificCD8+Tcell.TheformationofCD274receptor/PD-L1orB7.1receptor/PD-L1ligandcomplextransmitsaninhibitorysignalwhichreducestheproliferationoftheseCD8+TcellsatthelymphnodesandsupplementarytothatCD274isalsoabletocontroltheaccumulationofforeignantigenspecificTcellsinthelymphnodesthroughapoptosiswhichisfurthermediatedbyalowerregulationofthegeneBcl-2. |
| Expression | CD274ishighlyexpressedintheheart,skeletalmuscle,placentaandlung.Weaklyexpressedinthethymus,spleen,kidneyandliver.ExpressedonactivatedT-andB-cells,dendriticcells,keratinocytesandmonocytes.CD274isaSingle-passtypeImembraneproteinandamemberoftheBTN/MOGgroupintheimmunoglobulinsuperfamily. |
| ImplicationsinDisease | UpregulationofCD274mayallowcancerstoevadethehostimmunesystem.Ananalysisof196tumorspecimensfrompatientswithrenalcellcarcinomafoundthathightumorexpressionofCD274wasassociatedwithincreasedtumoraggressivenessanda4.5-foldincreasedriskofdeath.OvariancancerpatientswithhigherexpressionofCD274hadasignificantlypoorerprognosisthanthosewithlowerexpression.CD274expressioncorrelatedinverselywithintraepithelialCD8+T-lymphocytecount,suggestingthatCD274ontumorcellsmaysuppressantitumorCD8+Tcells.ThishasencourageddevelopmentofCD274inhibitorswhichAsofApril2013havestartedclinicaltrials.Theeffectmightbetumortypedependant;astudyonpatientswithnon-smallcelllungcancershowedthatgreaterPD-L1proteinandmRNAexpressionisassociatedwithincreasedlocallymphocyticinfiltrateandlongersurvival. |
| SequenceInformation | CD274contains290aminoacidsandhasamolecularweightof33275Da.Itcontains1Ig-likeC2-type(immunoglobulin-like)domain. |
| Post-TranslationalModifications | CD274undergoesglycosylationatAsn35,Asn192,Asn200andAsn219. |
| DatabaseLinks | EntrezGene:29126Human,Omim:605402Human,SwissProt:Q9NZQ7Human,Unigene:521989Human |
品牌介绍
美国Fitzgerald 公司是一家国际性知名抗体研发生产企业。Fitzgerald公司为全球试剂诊断公司与研究机构提供专业的抗体、纯化抗原以及工业诊断用大包装免疫原料。公司产品多达5000种，能够满足您对于最前沿科学研究的需求。产品涉及：单克隆抗体／抗原生育类、传染病类、TORCH系列、肿瘤标记物、心脏标记物、神经科学类、病毒类等等。
品牌分类
重组蛋白
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