Fitzgerald/CHK1 antibody/10R-8603/100 ul
商品编号：
10R-8603-100ul
品牌：
fitzgerald-fii
市场价：
¥5900.00
美元价：
4425.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
OVERVIEW:
| Synonyms | Monoclonal CHK1 antibody, Anti-CHK1 antibody, CHEK1 antibody, checkpoint kinase 1 antibody, 2720 antibody, BOS_24586 antibody, C85740 antibody, cell cycle checkpoint kinase antibody, CH211-257I19.3 antibody, checkpoint kinase-1 antibody, checkpoint kinase 1 homolog antibody, Checkpoint antibody, S. pombe antibody, homolog of antibody, 1 antibody, chk1 antibody, CHK1 checkpoint homolog antibody, CHK1 checkpoint homolog (S. pombe) antibody, Chk1 checkpoint kinase antibody, Chk1-S antibody, rad27 antibody, rad27 homolog antibody, serine/threonine-protein kinase Chk1 antibody, xChk1 antibody |
|---|---|
| Cross Reactivity | Human, Rat |
| Applications | WB |
| Immunogen | CHK1 antibody was raised in Mouse using a recombinant human protein purified from E.coli (His-CHK1) as the immunogen |
SPECIFICATIONS:
| Host | Mouse |
|---|---|
| Clone | AF2B11 |
| Isotype | IgG1 kappa |
| Method of Purification | CHK1 antibody was purified by ammonium sulfate precipitation |
| Form & Buffer | Supplied in liquid form in HEPES buffer with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol |
STORAGE & SAFETY:
| Storage | Aliquot and store for 1 year at -20 deg C, avoid freeze/thaw cycles |
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Usage Assay Information:
| Usage Recommendations | WB: 1:1000 |
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GENERAL INFORMATION:
| Biological Significance | Check point kinase 1 (Chk1) is a serine / threonine protein kinase and a key mediator in the DNA damage-induced checkpoint network. Chk1 is an evolutionarily conserved protein kinase that functions to ensure genomic integrity upon genotoxic stress. When the G2 or S checkpoint is abrogated by the inhibition of Chk1, p53-deficient cancer cells undergo mitotic catastrophe and eventually apoptosis, whereas normal cells are still arrested in the G1 phase. Thus, Chk1 inhibitors can preferentially potentiate the efficacy of DNA damaging agents in cancer cells, and Chk1 is an attractive therapeutic target for cancer treatment, especially since approximately 50% of all human cancers are p53-deficient. |
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品牌介绍
美国Fitzgerald 公司是一家国际性知名抗体研发生产企业。Fitzgerald公司为全球试剂诊断公司与研究机构提供专业的抗体、纯化抗原以及工业诊断用大包装免疫原料。公司产品多达5000种，能够满足您对于最前沿科学研究的需求。产品涉及：单克隆抗体／抗原生育类、传染病类、TORCH系列、肿瘤标记物、心脏标记物、神经科学类、病毒类等等。
品牌分类
重组蛋白
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