Fitzgerald/PRAK antibody/10R-8478/100 ul
商品编号：
10R-8478-100ul
品牌：
fitzgerald-fii
市场价：
¥5900.00
美元价：
4425.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
OVERVIEW:
| Synonyms | Monoclonal PRAK antibody, Anti-PRAK antibody, MAPKAPK5 antibody, mitogen-activated protein kinase-activated protein kinase 5 antibody, BOS_16625 antibody, EGK_04198 antibody, MAPK-activated protein kinase 5 antibody, MAPKAP-K5 antibody, MAPKAPK-5 antibody, MAPKAP kinase 5 antibody, MAP kinase-activated protein kinase 5 antibody, MK5 antibody, MK-5 antibody, p38-regulated/activated protein kinase antibody, prak antibody, TGas086c06.1 antibody |
|---|---|
| Cross Reactivity | Human, Mouse, Rat |
| Applications | ELISA, WB |
| Immunogen | PRAK antibody was raised in Mouse using a recombinant human protein purified from E.coli (His-PRAK) as the immunogen |
SPECIFICATIONS:
| Host | Mouse |
|---|---|
| Clone | 13H5 |
| Isotype | IgG1 kappa |
| Method of Purification | PRAK antibody was purified by ammonium sulfate precipitation |
| Form & Buffer | Supplied in liquid form in HEPES buffer with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol |
STORAGE & SAFETY:
| Storage | Aliquot and store for 1 year at -20 deg C, avoid freeze/thaw cycles |
|---|
Usage Assay Information:
| Usage Recommendations | WB: 1:5000 -10000 |
|---|
GENERAL INFORMATION:
| Biological Significance | PRAK is a 471 amino acid protein with 20-30% sequence identity to the known MAP kinase-regulated protein kinases RSK1/2/3, MNK1/2 and MAPKAPK2/3. The p38 mitogen-activated protein kinase (MAPK) pathway plays an important role in cellular responses to inflammatory stimuli and environmental stress. There are at least six protein kinases that can be regulated by p38alpha and/or p38beta. These downstream kinases of p38s include MAPK-activated protein kinase 2 (MAPKAPK2 or MK2), MAPKAPK3, MAPK-interacting kinase 1 (MNK1), MNK2, p38-activated/regulated protein kinase (PRAK or MAPKAPK5), and mitogen- and stress-activated protein kinase (MSK). PRAK can be activated in response to cellular stress and proinflammatory cytokines. T182 within the activation loop of PRAK has been determined to be the regulatory phosphorylation site. PRAK has been reoprted to be essential for ras-induced senescence and tumor suppression. PRAK mediates senescence upon activation by p38 in response to oncogenic ras. |
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品牌介绍
美国Fitzgerald 公司是一家国际性知名抗体研发生产企业。Fitzgerald公司为全球试剂诊断公司与研究机构提供专业的抗体、纯化抗原以及工业诊断用大包装免疫原料。公司产品多达5000种，能够满足您对于最前沿科学研究的需求。产品涉及：单克隆抗体／抗原生育类、传染病类、TORCH系列、肿瘤标记物、心脏标记物、神经科学类、病毒类等等。
品牌分类
重组蛋白
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