Fitzgerald/Rad50 antibody/10R-8636/100 ul
商品编号：
10R-8636-100ul
品牌：
fitzgerald-fii
市场价：
¥5900.00
美元价：
4425.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
OVERVIEW:
| Synonyms | Monoclonal Rad50 antibody, Anti-Rad50 antibody, RAD50 antibody, RAD50 homolog (S. cerevisiae) antibody, 6339 antibody, BOS_7802 antibody, CG6339 gene product from transcript CG6339-RE antibody, CG6339-PD antibody, CG6339-PE antibody, Dmel_CG6339 antibody, Dmrad50 antibody, DNA repair protein RAD50 antibody, GLEAN_15093 antibody, hRad50 antibody, mRad50 antibody, Mrell antibody, NBSLD antibody, RAD502 antibody, RAD50 homolog antibody, Rad50l antibody, rad50-PD antibody, rad50-PE antibody, RP23-239O19.3 antibody, TcasGA2_TC015093 antibody |
|---|---|
| Cross Reactivity | Human, Mouse, Rat |
| Applications | IP, WB |
| Immunogen | Rad50 antibody was raised in Mouse using a recombinant human protein purified from E.coli (His-Rad50) as the immunogen |
SPECIFICATIONS:
| Host | Mouse |
|---|---|
| Clone | 20B5 |
| Isotype | IgG2b kappa |
| Form & Buffer | Supplied in liquid form in HEPES buffer with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol |
STORAGE & SAFETY:
| Storage | Aliquot and store for 1 year at -20 deg C, avoid freeze/thaw cycles |
|---|
Usage Assay Information:
| Usage Recommendations | WB: 1:2000, IP: 5 ug |
|---|
GENERAL INFORMATION:
| Biological Significance | RAD50 is a component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11A to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation. |
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品牌介绍
美国Fitzgerald 公司是一家国际性知名抗体研发生产企业。Fitzgerald公司为全球试剂诊断公司与研究机构提供专业的抗体、纯化抗原以及工业诊断用大包装免疫原料。公司产品多达5000种，能够满足您对于最前沿科学研究的需求。产品涉及：单克隆抗体／抗原生育类、传染病类、TORCH系列、肿瘤标记物、心脏标记物、神经科学类、病毒类等等。
品牌分类
重组蛋白
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