Fitzgerald/Retinoblastoma protein antibody/10R-8455/100 ul
商品编号：
10R-8455-100ul
品牌：
fitzgerald-fii
市场价：
¥6720.00
美元价：
5040.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
OVERVIEW:
| Synonyms | Monoclonal Retinoblastoma protein antibody, Anti-Retinoblastoma protein antibody, RB1 antibody, retinoblastoma 1 antibody, BOS_12359 antibody, OSRC antibody, p104 antibody, P105-RB antibody, pp105 antibody, PP110 antibody, pRb antibody, Rb antibody, Rb-1 antibody, RB11 antibody, retinoblastoma antibody, Retinoblastoma 1 (including osteosarcoma) antibody, retinoblastoma-associated protein antibody, retinoblastoma protein antibody, retinoblastoma protein 1 antibody, retinoblastoma antibody, susceptibility antibody, retinoblastoma suspectibility protein antibody, RP11-174I10.1 antibody |
|---|---|
| Cross Reactivity | Human |
| Applications | ELISA, IP, WB |
| Immunogen | Retinoblastoma protein antibody was raised in Mouse using a recombinant human protein purified from E.coli as the immunogen |
SPECIFICATIONS:
| Host | Mouse |
|---|---|
| Clone | 7E6 |
| Isotype | IgG1 kappa |
| Method of Purification | Retinoblastoma protein antibody was purified by ammonium sulfate precipitation |
| Form & Buffer | Supplied in liquid form in HEPES buffer with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol |
STORAGE & SAFETY:
| Storage | Aliquot and store for 1 year at -20 deg C, avoid freeze/thaw cycles |
|---|
Usage Assay Information:
| Usage Recommendations | WB: 1:2000, IP: 1 ul |
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GENERAL INFORMATION:
| Biological Significance | The Rb protein (pRb, 110 kDa) is a tumor suppressor, which plays a pivotal role in the negative control of the cell cycle and in tumor progression. pRb is responsible for a major G1 checkpoint, blocking S-phase entry and cell growth. pRb prevents the cell from replicating damaged DNA by preventing its progression through the cell cycle into its S phase or progressing through G1 phase. pRb can actively inhibit cell cycle progression when it is dephosphorylated while this function is inactivated when pRb is phosphorylated. pRb is activated near the end of mitosis (M phase) when a phosphatase dephosphorylates it, allowing it to bind E2F. The pRb protein represses gene transcription, required for transition from G1 to S phase, by directly binding to the transactivation domain of E2F and by binding to the promoter of these genes as a complex with E2F. |
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品牌介绍
美国Fitzgerald 公司是一家国际性知名抗体研发生产企业。Fitzgerald公司为全球试剂诊断公司与研究机构提供专业的抗体、纯化抗原以及工业诊断用大包装免疫原料。公司产品多达5000种，能够满足您对于最前沿科学研究的需求。产品涉及：单克隆抗体／抗原生育类、传染病类、TORCH系列、肿瘤标记物、心脏标记物、神经科学类、病毒类等等。
品牌分类
重组蛋白
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