Fitzgerald/SMAD1/5 antibody/10R-8575/100 ul
商品编号：
10R-8575-100ul
品牌：
fitzgerald-fii
市场价：
¥5900.00
美元价：
4425.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
OVERVIEW:
| Synonyms | Monoclonal SMAD1/5 antibody, Anti-SMAD1/5 antibody, SMAD1 antibody, SMAD family member 1 antibody, BMP pathway effector antibody, BMP signal transducer SMAD1 antibody, BOS_16283 antibody, BSP1 antibody, BSP-1 antibody, dwarfin-A antibody, dwf-A antibody, EGK_16135 antibody, fb39h09 antibody, hypothetical protein antibody, jv41 antibody, JV4-1 antibody, madh1 antibody, MAD homolog 1 antibody, MAD homolog 1 (Drosophila) antibody, MAD homolog1 (mothers against decapentaplegic antibody, Drosophila) antibody, MAD (mothers against decapentaplegic antibody, Drosophila) homolog 1 antibody, MAD antibody, mothers against decapentaplegic homolog 1 antibody, Madr1 antibody, mad-related protein 1 antibody, Mlp1 antibody, mMad1 antibody, mothers against decapentaplegic homolog 1 antibody, mothers against decapentaplegic-like protein 1 antibody, mothers against DPP homolog 1 antibody, mothers-against-DPP-related 1 antibody, MusMLP antibody, SMA- and MAD-related protein 1 antibody, SMAD-1 antibody, SMAD 1 antibody, SMAD antibody, mothers against DPP homolog 1 antibody, TGF-beta signaling protein 1 antibody, transforming growth factor-beta signaling protein 1 antibody, transforming growth factor-beta-signaling protein 1 antibody, Xmad1 antibody, XSMAD1 antibody |
|---|---|
| Cross Reactivity | Human, Rat |
| Applications | ELISA, WB |
| Immunogen | SMAD1/5 antibody was raised in Mouse using a recombinant human protein purified from E.coli (His-SMAD1) as the immunogen |
SPECIFICATIONS:
| Host | Mouse |
|---|---|
| Clone | AF10B7 |
| Isotype | IgG2a kappa |
| Method of Purification | SMAD1/5 antibody was purified by ammonium sulfate precipitation |
| Form & Buffer | Supplied in liquid form in HEPES buffer with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol |
STORAGE & SAFETY:
| Storage | Aliquot and store for 1 year at -20 deg C, avoid freeze/thaw cycles |
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Usage Assay Information:
| Usage Recommendations | WB: 1:1000-2000 |
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GENERAL INFORMATION:
| Biological Significance | In mammals, eight SMAD proteins have been identified to date. The SMAD family of proteins can be divided into three functional groups: the receptor-activated SMADs (R-SMADs), common mediator SMADs (Co-SMADs), and the inhibitory SMADs (I-SMADs). The R-SMADs are directly phosphorylated by the activated type I receptors on their C-terminal Ser-Ser-X-Ser (SSXS) motif and include SMAD1, SMAD2, SMAD3, SMAD5, and SMAD8. SMAD2 and SMAD3 are phosphorylated in response to TGF-beta and activin, whereas SMAD1, SMAD5, and SMAD8 are phosphorylated in response to BMP (Bone Morphogenetic Protein). This C-terminal phosphorylation allows R-SMAD binding to Co-SMAD, SMAD4, and translocation to the nucleus where they regulate TGF-beta target genes. SMAD6 and SMAD7 belong to the I-SMAD which bind to the type I receptor or SMAD4 and block their interaction with R-SMADs. |
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品牌介绍
美国Fitzgerald 公司是一家国际性知名抗体研发生产企业。Fitzgerald公司为全球试剂诊断公司与研究机构提供专业的抗体、纯化抗原以及工业诊断用大包装免疫原料。公司产品多达5000种，能够满足您对于最前沿科学研究的需求。产品涉及：单克隆抗体／抗原生育类、传染病类、TORCH系列、肿瘤标记物、心脏标记物、神经科学类、病毒类等等。
品牌分类
重组蛋白
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