菲茨杰拉德/ZAP70抗体/10R-8480/100微升
商品编号：
10R-8480-100ul
品牌：
fitzgerald-fii
市场价：
¥6720.00
美元价：
5040.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
OVERVIEW:
| Synonyms | Monoclonal ZAP70 antibody, Anti-ZAP70 antibody, ZAP70 antibody, zeta-chain (TCR) associated protein kinase 70kDa antibody, 70kDa antibody, 70 kDa zeta-associated protein antibody, 70 kDa zeta-chain associated protein antibody, BOS_11303 antibody, DKEY-45M5.3 antibody, mrtle antibody, mur antibody, SRK antibody, STD antibody, syk-related protein tyrosine kinase antibody, syk-related tyrosine kinase antibody, tyrosine-protein kinase ZAP-70 antibody, TZK antibody, ZAP-70 antibody, zeta-chain associated protein kinase antibody, 70kD antibody, zeta-chain associated protein kinase 70kDa antibody, zeta-chain (TCR) associated protein kinase antibody, zeta-chain (TCR) associated protein kinase 70 antibody |
|---|---|
| Cross Reactivity | Human |
| Applications | ELISA, IP, WB |
| Immunogen | ZAP70 antibody was raised in Mouse using a recombinant human protein purified from E.coli (ABD-ZAP70) as the immunogen |
SPECIFICATIONS:
| Host | Mouse |
|---|---|
| Clone | 49B4 |
| Isotype | IgG1 kappa |
| Method of Purification | ZAP70 antibody was purified by ammonium sulfate precipitation |
| Form & Buffer | Supplied in liquid form in HEPES buffer with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol |
STORAGE & SAFETY:
| Storage | Aliquot and store for 1 year at -20 deg C, avoid freeze/thaw cycles |
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Usage Assay Information:
| Usage Recommendations | WB: 1:10000, IP: 2 ul |
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GENERAL INFORMATION:
| Biological Significance | ZAP70 is a 70 kDa member of the Syk family kinase predominantly involved in T cell receptor (TCR) signaling. It is structurally homologous to Syk, a PTK that is involved in proximal BCR signaling. ZAP-70 is a key signaling molecule in T cell activation and also plays a role in apoptosis and cell migration. SYK family tyrosine kinases contain a C-terminal kinase domain and tandem N-terminal SH2 domains that bind phosphorylated ITAMs (immunoreceptor tyrosine-based activation motif). Linker region that contains multiple tyrosines separates the SH2 domains from the kinase domain. Phosphorylated tyrosines act as docking sites for phospholipase Cgamma1 (PLCgamma1). ZAP-70 and Syk are functionally homologous in antigen receptor signaling. Expression of ZAP-70 in Syk- B cells reconstitutes SCR function. Reconstitution requires the presence of functional Src homology 2 (SH2) and catalytic domains of ZAP-70. Expression of ZAP-70 is an important negative prognostic factor in chronic lymphocytic leukemia (CLL) with more rapid disease progression and shorter survival. |
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品牌介绍
美国Fitzgerald 公司是一家国际性知名抗体研发生产企业。Fitzgerald公司为全球试剂诊断公司与研究机构提供专业的抗体、纯化抗原以及工业诊断用大包装免疫原料。公司产品多达5000种，能够满足您对于最前沿科学研究的需求。产品涉及：单克隆抗体／抗原生育类、传染病类、TORCH系列、肿瘤标记物、心脏标记物、神经科学类、病毒类等等。
品牌分类
重组蛋白
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